生物

Linda J. Noble-Haeusslein obtained her degree in physical therapy from the University of Utah and her doctoral degree in Anatomy from the UCLA. She is currently Professor and Alvera Kan Endowed Chair, Departments of Neurological Surgery and Physical Therapy and Rehabilitation Science at the University of California at San Francisco (UCSF) and is a member of the Graduate Programs in Neuroscience and Biomedical Sciences. She is also the Co-Director of the Neurobehavioral Core for Rehabilitation Research at UCSF, which is dedicated to phenotyping murine models of neurologic-based diseases and assessing efficacy of interventions including rehabilitation. The Noble-Haeusslein laboratory studies the key determinants of injury and repair in murine models of traumatic injury to the developing brain and the adult spinal cord. The focus is on the intersection between the innate immune response, matrix metalloproteinases, and specific receptors on leukocytes that modulate demyelination. A second area of research addresses stem cells as modifiers of circuitry that control bladder function and nociception in the injured spinal cord. Using embryonic medial ganglionic eminence cells, the primary source of GABAergic inhibitory interneurons, ongoing studies are evaluating their ability to modify synaptic function and reduce hyperexcitability in circuitry that are responsible for bladder dyssynergia and pain syndromes. Dr. Noble-Haeusslein has served as regular member and chair of the NINDS NSDA study section, is a regular ad hoc reviewer for NINDS, and has participated on three Institute of Medicine Committees that have addressed traumatic brain injury from the perspectives of its long term consequences and early nutritional support. Her studies on traumatic brain and spinal cord injuries have been funded by the Department of Defense, NIH/NINDS, Craig H. Neilsen Foundation, and the California Institute For Regenerative Medicine.