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学生对 加州大学圣地亚哥分校 提供的 Genome Assembly Programming Challenge 的评价和反馈

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281 个评分
52 条评论

课程概述

In Spring 2011, thousands of people in Germany were hospitalized with a deadly disease that started as food poisoning with bloody diarrhea and often led to kidney failure. It was the beginning of the deadliest outbreak in recent history, caused by a mysterious bacterial strain that we will refer to as E. coli X. Soon, German officials linked the outbreak to a restaurant in Lübeck, where nearly 20% of the patrons had developed bloody diarrhea in a single week. At this point, biologists knew that they were facing a previously unknown pathogen and that traditional methods would not suffice – computational biologists would be needed to assemble and analyze the genome of the newly emerged pathogen. To investigate the evolutionary origin and pathogenic potential of the outbreak strain, researchers started a crowdsourced research program. They released bacterial DNA sequencing data from one of a patient, which elicited a burst of analyses carried out by computational biologists on four continents. They even used GitHub for the project: https://github.com/ehec-outbreak-crowdsourced/BGI-data-analysis/wiki The 2011 German outbreak represented an early example of epidemiologists collaborating with computational biologists to stop an outbreak. In this Genome Assembly Programming Challenge, you will follow in the footsteps of the bioinformaticians investigating the outbreak by developing a program to assemble the genome of the E. coli X from millions of overlapping substrings of the E.coli X genome....

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SH
Oct 20, 2020

Really enjoyable and also challenging specialization. I also enjoyed this capstone too. I gathered my interest in Algorithms and Bioinformatics field.

AS
Aug 4, 2018

I would like to say thank you to all who have created this course and specialization! Good material, excellent lecturers!

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51 - Genome Assembly Programming Challenge 的 52 个评论(共 52 个)

创建者 Dmitri M

May 9, 2017

I wish I had the choice of pursuing graph algorithms, when I signed up for the specialization with the promise of selecting one of the two Capstone projects. Bioinformatics? I wanted the other one on practical graph algorithm applications. There are already two dedicated courses by Pevzner and et al, which would have prepared us better for this too specialized and impractical Capstone project...

创建者 Bohdan S

Feb 21, 2021

Couldn't find any good explanation why THIS is included as the specialization's last course. It just makes no sense.