0:09
Hello and welcome Claus.
>> In this session we'll talk about dynotics of bacteria and
chronic infections.
So in your everyday life as a chemical biologist,
why do we need to diagnose bacteria in infections?
>> Well it's very important to diagnose microorganisms to see what other patient
symptoms are caused by a micro organism, whether it's an infectious disease or not.
It's also nice to have the microorganisms to see if we can provide
susceptibility pattern against antimicrobial agents of the pathogen.
Some pathogens also have to be treated in special ways, for
example, with combination of therapy In different ways.
1:09
Fighting of some microorganisms may also lead to further examinations.
And, given, a hint on, what could be the entrance of the micro,
microorganisms, what could be the primary focus of the microorganism.
1:28
>> Okay.
>> And in some cases it's also important to know whether, es,
especially if the patient symptoms continue whether it's a,
a new infection or it's a chronic infection with the same microorganism.
>> Okay.
So in this course we learned there are both acute infections and, and
chronic infections and I guess that acute infections are fairly easy to diagnose,
but why is it so difficult to diagnose bacteria and chronic infections?
2:00
>> It, it's true on acute infections that in many,
of course it's still important to diagnose them, but in, in these cases it's
also very, very important to initiate antibiotic treatment as soon as possible.
2:16
I will also say that in recent years there's been much more knowledge about
dealing with chronic infections so it's, it's easier today to, to
advise on these infections but for chronic infections and bathroom infections,
bacteria and fungi can have adapted to a new environment they live in.
They can be more difficult to culture, there can be fewer microorganisms
to culture so they can also be more difficult to, to identify in this way.
They can adhere to foreign bodies, for example,
and have to be detached before we can really identify them.
They, they can also have been initiated as part of a treatment, which also inhibits
the identification of the bacteria, especially the, the culture based methods.
So, I think these are the, the most important reasons, yeah.
3:13
>> Yeah.
And in, in your everyday work what, what's the biggest challenge in,
in, for diagnosing bacterial and chronic infections?
>> Well many of these infections are, are due to implants, and we have more and
more patients experiencing implants in, in, s, various ways.
3:36
Many patients today also have severe immunosuppression.
Antibiotic resistances is a challenge in these days.
Shorter admission time in the hospitals,
frequent transfer of the patients between hospitals.
And to the lack of new antibiotics,
development of new antibiotics, especially against gram negative bacteria.
These are some of the, the most important challenges I think.
>> Mm-hm.
So, for the future both as for the bacteria but also for, for
diagnostics, what, what, what, what will the future bring?
4:12
>> Well, I think we will have, probably more resistance to antibiotics.
I must also say that there are some programs developed for,
which can encourage the industry to develop new antbioti, biotics, so
it, they, they, it, it may be changing now.
And then new diagnostic methods are developing all the time,
our understanding of bathroom infections.
We know better how to handle the material.
For example by more different growth systems advanced microscopy methods and
these new molecular diagnostic methods are some of the,
the very important things I, I think.
Especially for, for culture methods we have included
ultrasound treatment of foreign bodies and so on, which improves the Identification
of the bacteria, both culture based and non culture based methods.
And then, of course, we have more and more non culture based methods,
advanced, microscope techniques.
And, PCR molecular diagnostic techniques.
And, and this is just an, an ongoing thing with the non culture based methods.
>> Okay, so you're optimistic.
>> Ver, oh yes, very optimistic.
We see a constant improvement in diagnostics and treatment,
especially because knowledge within biofilms are increasing all the time.
So, yes, I, I'm, I'm optimistic.
>> Excellent.
Thank you, Claus.
>> Thank you for the invitation.
[MUSIC]
Thomas BjarnsholtProfessor
