课程信息
4.5
33 个评分
11 个审阅
Nerves, the heart, and the brain are electrical. How do these things work? This course presents fundamental principles, described quantitatively....
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Intermediate Level

中级

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Approx. 22 hours to complete

建议:6 hours/week...
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English

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Globe

100% 在线课程

立即开始,按照自己的计划学习。
Calendar

可灵活调整截止日期

根据您的日程表重置截止日期。
Intermediate Level

中级

Clock

Approx. 22 hours to complete

建议:6 hours/week...
Comment Dots

English

字幕:English...

教学大纲 - 您将从这门课程中学到什么

Week
1
Clock
完成时间为 3 小时

Electricity in Solutions

This week's theme focuses on the foundations of bioelectricity including electricity in solutions. The learning objectives for this week are: (1) Explain the conflict between Galvani and Volta; (2) Interpret the polarity of Vm in terms of voltages inside as compared to outside cells; (3) Interpret the polarity of Im in terms of current flow into or out of a cell.; (4) Determine the energy in Joules of an ordinary battery, given its specifications; (5) State the “big 5” electrical field variables (potentials, field, force, current, sources) and be able to compute potentials from sources (the basis of extracellular bioelectric measurements such as the electrocardiogram) or find sources from potentials....
Reading
12 个视频(共 66 分钟), 5 个阅读材料, 2 个测验
Video12 个视频
What is the Question5分钟
About Bioelectricity5分钟
Major Sections of the Course5分钟
Rectification of Names10分钟
Ions in Solution6分钟
Core-Conductor Model of a Nerve Fiber9分钟
Potential and Voltages in the Fiber5分钟
Axial Currents in the Fiber5分钟
Membrane Resistance3分钟
Membrane Current, Failure & Mystery3分钟
Week 1 in Review4分钟
Reading5 个阅读材料
Welcome to the Course分钟
Assessments, Grading and Certificates10分钟
Course Lecture Slides10分钟
Discussion Forums10分钟
Reference Text10分钟
Quiz2 个练习
Quiz 1A10分钟
Quiz 1B16分钟
Week
2
Clock
完成时间为 2 小时

Energy into Voltage

This week we will examine energy, by which pumps and channels allow membranes to "charge their batteries" and thereby have a non-zero voltage across their membranes at rest. The learning objectives for this week are: (1) Describe the function of the sodium-potassium pump; (2) State from memory an approximate value for RT/F; (3) Be able to find the equilibrium potential from ionic concentrations and relative permeabilities; (4) Explain the mechanism by which membranes use salt water to create negative or positive trans-membrane voltages....
Reading
12 个视频(共 76 分钟), 2 个测验
Video12 个视频
A Membrane Patch; the Idea of It7分钟
Energy as Trans-membrane Voltage Vm3分钟
Sodium-potassium Pumps4分钟
Ionic equilibrium13分钟
Battery lifetime5分钟
Problem session 14分钟
Membrane Resistance Rm9分钟
Membrane capacitance Cm4分钟
Why is Cm so big?7分钟
Problem session, R and C8分钟
Week 2 summary5分钟
Quiz2 个练习
Quiz 2A20分钟
Quiz 2B12分钟
Week
3
Clock
完成时间为 2 小时

Passive and Active Resonses, Channels

This week we'll be discussing channels and the remarkable experimental findings on how membranes allow ions to pass through specialized pores in the membrane wall. The learning objectives for this week are: (1) Describe the passive as compared to active responses to stimulation; (2) Describe the opening and closing of a channel in terms of probabilities; (3) Given the rate constants alpha and beta at a fixed Vm, determine the channel probabilities; (4) Compute how the channel probabilities change when voltage Vm changes....
Reading
12 个视频(共 82 分钟), 1 个阅读材料, 3 个测验
Video12 个视频
Why are passive and active so different?3分钟
The simulation set-up9分钟
The passive simulation11分钟
The active simulation11分钟
Where does the active response come from?8分钟
Problem session, passive v active6分钟
Channels: Experimental isolation of a channel7分钟
Channels: Observed currents, voltage step4分钟
Channels: Probability of being open6分钟
Problem session, Channel probabilities8分钟
Week 3 Conclusions4分钟
Reading1 个阅读材料
Alpha Beta Programming Assignment Instructions10分钟
Quiz3 个练习
Quiz 3A12分钟
Quiz 3B18分钟
Alpha Beta Programming Assignment24分钟
Week
4
Clock
完成时间为 3 小时

Hodgkin-Huxley Membrane Models

This week we will examine the Hodgkin-Huxley model, the Nobel-prize winning set of ideas describing how membranes generate action potentials by sequentially allowing ions of sodium and potassium to flow. The learning objectives for this week are: (1) Describe the purpose of each of the 4 model levels 1. alpha/beta, 2. probabilities, 3. ionic currents and 4. trans-membrane voltage; (2) Estimate changes in each probability over a small interval $$\Delta t$$; (3) Compute the ionic current of potassium, sodium, and chloride from the state variables; (4) Estimate the change in trans-membrane potential over a short interval $$\Delta t$$; (5) State which ionic current is dominant during different phases of the action potential -- excitation, plateau, recovery....
Reading
12 个视频(共 95 分钟), 1 个阅读材料, 3 个测验
Video12 个视频
What is the Problem8分钟
HH replacement for Rm5分钟
The equation for each pathway10分钟
Changes in n, m, h11分钟
Equations for alphas and betas18分钟
Problem session, I_Na9分钟
Putting it all together6分钟
Changes in n, m, h, and Vm5分钟
Numerical calculations, time and space6分钟
Problem session, a Vm step4分钟
Week 4 conclusions5分钟
Reading1 个阅读材料
Action Potential Programming Assignment10分钟
Quiz3 个练习
Quiz 4A16分钟
Quiz 4B20分钟
Action Potential Programming Assignment18分钟
4.5

热门审阅

创建者 JRSep 25th 2016

Very clear expectations, and the lectures were spaced out nicely to cover material while not being overwhelming. Additionally, the analogies used to convey the principles were clever and helpful!

创建者 AJJan 15th 2018

Interesting class which derived mathematical models that were, and are still used, to describe nerves.

讲师

Dr. Roger Barr

Anderson-Rupp Professor of Biomedical Engineering and Associate Professor of Pediatrics
Biomedical Engineering, Pediatrics

关于 Duke University

Duke University has about 13,000 undergraduate and graduate students and a world-class faculty helping to expand the frontiers of knowledge. The university has a strong commitment to applying knowledge in service to society, both near its North Carolina campus and around the world....

常见问题

  • Once you enroll for a Certificate, you’ll have access to all videos, quizzes, and programming assignments (if applicable). Peer review assignments can only be submitted and reviewed once your session has begun. If you choose to explore the course without purchasing, you may not be able to access certain assignments.

  • When you purchase a Certificate you get access to all course materials, including graded assignments. Upon completing the course, your electronic Certificate will be added to your Accomplishments page - from there, you can print your Certificate or add it to your LinkedIn profile. If you only want to read and view the course content, you can audit the course for free.

  • No. Completion of a Coursera course does not earn you academic credit from Duke; therefore, Duke is not able to provide you with a university transcript. However, your electronic Certificate will be added to your Accomplishments page - from there, you can print your Certificate or add it to your LinkedIn profile.

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