A big welcome to “Bioinformatics: Introduction and Methods” from Peking University! In this MOOC you will become familiar with the concepts and computational methods in the exciting interdisciplinary field of bioinformatics and their applications in biology, the knowledge and skills in bioinformatics you acquired will help you in your future study and research.
Course materials are available under the CC BY-NC-SA License.
教学大纲 - 您将从这门课程中学到什么
周
1完成时间为 2 小时
Introduction and History of Bioinformatics
Welcome to “Bioinformatics: Introduction and Methods! Upon completion of this module you will be able to: become familiar with the essential concepts of bioinformatics; explore the history of this young area; experience how rapidly bioinformatics is growing. Our supplementary materials will give you a better understanding of the course lectures through they are not required in quizzes or exams
4 个视频 （总计 69 分钟）, 2 个阅读材料, 1 个测验
4 个视频
History of Bioinformatics30分钟
Bioinformatics in Mainland China8分钟
About This Course9分钟
2 个阅读材料
Readings10分钟
Slides10分钟
1 个练习
Introduction and History of Bioinformatics20分钟
周
2完成时间为 2 小时
Sequence Alignment
Upon completion of this module, you will be able to: describe dynamic programming based sequence alignment algorithms; differentiate between the Needleman-Wunsch algorithm for global alignment and the Smith-Waterman algorithm for local alignment; examine the principles behind gap penalty and time complexity calculation which is crucial for you to apply current bioinformatic tools in your research; experience the discovery of Smith-Waterman algorithm with Dr. Michael Waterman himself.
7 个视频 （总计 99 分钟）, 2 个阅读材料, 1 个测验
7 个视频
Global Alignment by Dynamic Programming14分钟
From Global to Local6分钟
Alignment with Affine Gap Penalty and Calculation of Time Complexity of The Needleman-Wunsch Algorithm6分钟
Interview with M. S. Waterman Waterman29分钟
Supplement on Homology & Similarity, Similarity Matrix and Dot Matrix (English Subtitles)10分钟
Student Presentation (English Subtitles)18分钟
2 个阅读材料
Readings10分钟
Slides10分钟
1 个练习
Sequence Alignment18分钟
周
3完成时间为 1 小时
Sequence Database Search
Upon completion of this module, you will be able to: become familiar with sequence databse search and most common databases; explore the algoritm behind BLAST and the evaluation of BLAST results; ajdust BLAST parameters base on your own research project.
3 个视频 （总计 41 分钟）, 2 个阅读材料, 1 个测验
3 个视频
BLAST Algorithm: A Primer13分钟
Student Presentation (English Subtitles)15分钟
2 个阅读材料
Readings10分钟
Slides10分钟
1 个练习
Sequence Database Search10分钟
周
4完成时间为 1 小时
Markov Model
Upon completion of this module, you will be able to: recognize state transitions, Markov chain and Markov models; create a hidden Markov model by yourself; make predictuions in a real biological problem with hidden Markov model.
4 个视频 （总计 47 分钟）, 2 个阅读材料, 1 个测验
4 个视频
Hidden Markov Model11分钟
Predict with Hidden Markov Model10分钟
Student Presentation16分钟
2 个阅读材料
Readings10分钟
Slides10分钟
1 个练习
Markov Model 14分钟
4.7
30 个审阅40%
通过此课程获得实实在在的工作福利
25%
加薪或升职
热门审阅
The course has given me a great way to learn Bioinformatics. I especially loved the mode of teaching and the case studies.
讲师
Ge Gao 高歌, Ph.D.
Assistant Professor, Principle InvestigatorCenter for Bioinformatics, School of Life Science
Liping Wei 魏丽萍, Ph.D.
Professor, DirectorCenter for Bioinformatics, School of Life Sciences
关于 北京大学
Peking University is determined to make its education openly accessible to students in China and around the world. With over 3000 faculty members, Peking University offers excellence in teaching and learning.
Founded in 1898, Peking University (PKU) was the first national comprehensive university in China. For the past 115 years, with its hundreds of thousands of outstanding alumni, Peking University has made prominent contributions in the humanities and sciences to further China's prosperity and progress.
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