Clinical trials are experiments designed to evaluate new interventions to prevent or treat disease in humans. The interventions evaluated can be drugs, devices (e.g., hearing aid), surgeries, behavioral interventions (e.g., smoking cessation program), community health programs (e.g. cancer screening programs) or health delivery systems (e.g., special care units for hospital admissions). We consider clinical trials experiments because the investigators rather than the patients or their doctors select the treatment the patients receive. Results from randomized clinical trials are usually considered the highest level of evidence for determining whether a treatment is effective because trials incorporates features to ensure that evaluation of the benefits and risks of treatments are objective and unbiased. The FDA requires that drugs or biologics (e.g., vaccines) are shown to be effective in clinical trials before they can be sold in the US.
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临床试验的设计和解释
约翰霍普金斯大学课程信息
您将获得的技能
- Clinical Research
- Trial Design
- Clinical Trial Design
- Clinical Trial Management
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约翰霍普金斯大学
The mission of The Johns Hopkins University is to educate its students and cultivate their capacity for life-long learning, to foster independent and original research, and to bring the benefits of discovery to the world.
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Types of Trial Designs
This week, we explore different types of trial designs, including parallel, crossover, group allocation, factorial, large simple, equivalency, non-inferiority, and adaptive designs.
Randomization and Masking
This week we discuss two key design features of randomized clinical trials used to protect against bias, randomization and masking.
Outcomes and Analysis
This week focuses on a key design issue - selecting the primary outcome. We will also cover the gold standard for analysis of clinical trials, which is including all the participants in the analysis regardless of their actual treatment.
Ethics
This week focuses on a key issue in the field of clinical trials, the ethics of experimentation in humans.
审阅
- 5 stars76.06%
- 4 stars21.05%
- 3 stars2.45%
- 2 stars0.25%
- 1 star0.17%
来自临床试验的设计和解释的热门评论
The course is an excellent one for beginners on design and interpretation of clinical trials. The information provided by both the instructors were well presented, and clear. Thank you!
This course really helped me to understand trials and gave me starting knowledge about how to design a trial. But it is not enough itself, and you should consider taking biostatistics classes.
High quality course ! covering important areas and detailed lectures, more and better than a mere introduction. Congrats ! My only regret : I'd have liked to hear more about NI and equivalence trials
Great course! I was completely new to clinical trials, and now I feel that I can use what I learned to look for a job. Everything is explained very clearly. Thank you so much this course!
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