课程信息
4.7
370 个评分
81 个审阅
专项课程

第 1 门课程(共 7 门)

100% 在线

100% 在线

立即开始,按照自己的计划学习。
可灵活调整截止日期

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初级

初级

完成时间(小时)

完成时间大约为13 小时

建议:4-10 hours/week...
可选语言

英语(English)

字幕:英语(English)

您将获得的技能

BioinformaticsBioinformatics AlgorithmsAlgorithmsPython Programming
专项课程

第 1 门课程(共 7 门)

100% 在线

100% 在线

立即开始,按照自己的计划学习。
可灵活调整截止日期

可灵活调整截止日期

根据您的日程表重置截止日期。
初级

初级

完成时间(小时)

完成时间大约为13 小时

建议:4-10 hours/week...
可选语言

英语(English)

字幕:英语(English)

教学大纲 - 您将从这门课程中学到什么

1
完成时间(小时)
完成时间为 3 小时

Week 1: Welcome!

<p>Welcome to class!</p><p>This course will focus on two questions at the forefront of modern computational biology, along with the algorithmic approaches we will use to solve them in parentheses:</p><ol><li>Weeks 1-2: Where in the Genome Does DNA Replication Begin? (<em>Algorithmic Warmup</em>)</li><li>Weeks 3-4: Which DNA Patterns Play the Role of Molecular Clocks? (<em>Randomized Algorithms</em>)</li></ol><p>Week 5 will consist of a Bioinformatics Application Challenge in which you will get to apply software for finding DNA motifs to a real biological dataset.</p><p>Each of the two chapters in the course is accompanied by a Bioinformatics Cartoon created by Randall Christopher and serving as a chapter header in the Specialization's bestselling <a href="http://bioinformaticsalgorithms.com" target="_blank">print companion</a>. You can find the first chapter's cartoon at the bottom of this message. What does a cryptic message leading to buried treasure have to do with biology? We hope you will join us to find out!</p><p><img src="http://bioinformaticsalgorithms.com/images/cover/replication_cropped.jpg" title="Image: http://bioinformaticsalgorithms.com/images/cover/chapter1_cropped.jpg" width="500"></p><p><a href="http://compeau.cbd.cmu.edu" target="_blank"><img src="http://bioinformaticsalgorithms.com/images/Compeau_caricature.jpg" width ="150"></a> <a href="http://cseweb.ucsd.edu/~ppevzner/" target="_blank"><img src="http://bioinformaticsalgorithms.com/images/Pevzner_caricature.jpg" width ="150"></a></p><p>Phillip and Pavel</p>...
Reading
3 个视频 (总计 21 分钟), 3 个阅读材料, 3 个测验
Video3 个视频
Where in the Genome Does DNA Replication Begin? (Part 1) (11:37)11分钟
Where in the Genome Does DNA Replication Begin? (Part 2) (06:24)6分钟
Reading3 个阅读材料
Course Details10分钟
Week 1 FAQs (Optional)
What is Pseudocode? (Optional)1分钟
Quiz1 个练习
Week 1 Quiz15分钟
2
完成时间(小时)
完成时间为 3 小时

Week 2: Finding Replication Origins

<p>Welcome to Week 2 of class!</p> <p>This week, we will examine the biological details of how DNA replication is carried out in the cell. We will then see how to use these details to help us design an intelligent algorithmic approach looking for the replication origin in a bacterial genome.</p>...
Reading
2 个视频 (总计 13 分钟), 1 个阅读材料, 3 个测验
Video2 个视频
Where in the Genome Does DNA Replication Begin? (Part 4) (04:10)4分钟
Reading1 个阅读材料
Week 2 FAQs (Optional)
Quiz1 个练习
Week 2 Quiz15分钟
3
完成时间(小时)
完成时间为 4 小时

Week 3: Hunting for Regulatory Motifs

<p>Welcome to Week 3 of class!</p> <p>This week, we begin a new chapter, titled "Which DNA Patterns Play the Role of Molecular Clocks?" At the bottom of this message is this week's Bioinformatics Cartoon. &nbsp;What does a late night casino trip with two 18th Century French mathematicians have in common with finding molecular clocks? &nbsp;Start learning to find out...</p> <p><img src="https://d396qusza40orc.cloudfront.net/bioinformatics%2Fimages%2Fchapter3_final.jpg" title="Image: https://d396qusza40orc.cloudfront.net/bioinformatics%2Fimages%2Fchapter3_final.jpg" width="528"></p>...
Reading
3 个视频 (总计 23 分钟), 1 个阅读材料, 3 个测验
Video3 个视频
From Implanted Patterns to Regulatory Motifs (Part 2) (05:06)5分钟
From Implanted Patterns to Regulatory Motifs (Part 3) (07:22)7分钟
Reading1 个阅读材料
Week 3 FAQs (Optional)
Quiz1 个练习
Week 3 Quiz15分钟
4
完成时间(小时)
完成时间为 3 小时

Week 4: How Rolling Dice Helps Us Find Regulatory Motifs

<p>Welcome to Week 4 of class!</p> <p>Last week, we encountered a few introductory motif-finding algorithms. This week, we will see how to improve upon these motif-finding approaches by designing randomized algorithms that can "roll dice" to find motifs.</p>...
Reading
3 个视频 (总计 26 分钟), 1 个阅读材料, 3 个测验
Video3 个视频
How Rolling Dice Helps Us Find Regulatory Motifs (Part 2) (05:37)5分钟
How Rolling Dice Helps Us Find Regulatory Motifs (Part 3) (07:46)7分钟
Reading1 个阅读材料
Week 4 FAQs (Optional)
Quiz1 个练习
Week 4 Quiz15分钟
4.7
81 个审阅Chevron Right
职业方向

33%

完成这些课程后已开始新的职业生涯
工作福利

20%

通过此课程获得实实在在的工作福利

热门审阅

创建者 LLNov 13th 2017

Very tough but rewarding class. The programming part was easy, the algorithms kicked my butt. Love the challenge and can't wait to take the rest!!! Such an interesting field!

创建者 MPDec 4th 2017

Nice and recommended.\n\n(The final exam was a bit tedious though, with many points repeatedly given simply for "uploading the logo" and not much creative leeway)

讲师

Avatar

Pavel Pevzner

Professor
Department of Computer Science and Engineering
Avatar

Phillip Compeau

Visiting Researcher
Department of Computer Science & Engineering

关于 University of California San Diego

UC San Diego is an academic powerhouse and economic engine, recognized as one of the top 10 public universities by U.S. News and World Report. Innovation is central to who we are and what we do. Here, students learn that knowledge isn't just acquired in the classroom—life is their laboratory....

关于 Bioinformatics 专项课程

Join Us in a Top 50 MOOC of All Time! How do we sequence and compare genomes? How do we identify the genetic basis for disease? How do we construct an evolutionary Tree of Life for all species on Earth? When you complete this Specialization, you will learn how to answer many questions in modern biology that have become inseparable from the computational approaches used to solve them. You will also obtain a toolkit of existing software resources built on these computational approaches and that are used by thousands of biologists every day in one of the fastest growing fields in science. Although this Specialization centers on computational topics, you do not need to know how to program in order to complete it. If you are interested in programming, we feature an "Honors Track" (called "hacker track" in previous runs of the course). The Honors Track allows you to implement the bioinformatics algorithms that you will encounter along the way in dozens of automatically graded coding challenges. By completing the Honors Track, you will be a bioinformatics software professional! Learn more about the Bioinformatics Specialization (including why we are wearing these crazy outfits) by watching our introductory video. You can purchase the Specialization's print companion, Bioinformatics Algorithms: An Active Learning Approach, from the textbook website. Our first course, "Finding Hidden Messages in DNA", was named a top-50 MOOC of all time by Class Central!...
Bioinformatics

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