The neuroscience of drugs for therapy, for prevention, and for recreation. Drug addiction and drug abuse. You’ll learn the prospects for new generations of medications in neurology, psychiatry, aging, and treatment of substance abuse.
药物和大脑
提供方
加州理工学院
教学大纲 - 您将从这门课程中学到什么
周
1完成时间为 3 小时
Week 1. Organization and Overview
The description goes here
11 个视频 （总计 123 分钟）, 1 个测验
11 个视频
2. Organization and Overview, weeks 4- 7 9分钟
3. What is a Drug? 13分钟
4. Drug Entry Into the Nervous System 12分钟
5. Introduction to Drug Receptors 11分钟
6. More about receptors as proteins 13分钟
7. Introduction to Mammalian Brains 9分钟
8. Techniques for Studying the Brain 10分钟
9. Botulinum toxin 9分钟
10. Origin of the Resting Potential 10分钟
11. Electrical Aspects of Ion Channels 8分钟
1 个练习
Quiz on miniLectures 1-1136分钟
周
2完成时间为 2 小时
Week 2. Dose-response Relations
The description goes here
10 个视频 （总计 92 分钟）, 1 个测验
10 个视频
2 Quantitative Approaches, Agonist Only 10分钟
3 Agonists plus Antagonists 7分钟
1 The Synapse as a Drug-Sensitive Biophysical Machine 8分钟
2 Nicotinic Acetylcholine Receptors: Activation 10分钟
3 Nicotinic Acetylcholine Receptors: Desensitization 5分钟
4 Inhibitory Ligand-gated channels 9分钟
5 Glutamate-gated receptor channels 11分钟
1 Pore Blockers at ligand-gated channels 6分钟
2 Voltage-gated channel blockers 11分钟
1 个练习
Quiz on Week 2 miniLectures32分钟
周
3完成时间为 3 小时
Week 3. G protein pathways
The description goes here
10 个视频 （总计 118 分钟）, 1 个测验
10 个视频
2 Inhibitory G Proteins and their Effectors 7分钟
3 The Stimulatory G Protein (Gs) Pathway 11分钟
4 The Ca-mobilizing G protein (Gq) pathway; Modifying G protein Pathways 11分钟
5 “Outside-in” Mechanisms for Long-term Actions on G Protein Pathways 12分钟
1 Drugs Bind to Neurotransmitter Transporters 15分钟
2 Neurotransmitter Transporters as Molecules 11分钟
1 Overview 10分钟
2 Targets 8分钟
3 System level effects 14分钟
1 个练习
Quiz on Week 3 miniLectures38分钟
周
4完成时间为 3 小时
Week 4. Nicotine Addiction
The description goes here
12 个视频 （总计 145 分钟）, 1 个测验
12 个视频
2 Circuit and cellular level. "Outside-In" Mechanisms 11分钟
3 Circuit and Cellular Level: Upregulation via “Inside-Out” Mechanisms 16分钟
4 Recent Genetic Data 13分钟
5 Drugs for smoking cessation; Harm Reduction 14分钟
1 Components of Opiate Addiction 10分钟
2 Circuits and Animal Models 10分钟
3 “Outside-In” Mechanisms 12分钟
4 Drugs for Harm Reduction in Opiate Addiction 5分钟
1 Clinical Description & Genetics 10分钟
2 Pathophysiology 16分钟
3 Biomarkers & Therapeutic Approaches 8分钟
1 个练习
Quiz on Week 4 miniLectures30分钟
讲师
Henry A. Lester, PhD
Bren ProfessorDivision of Biology and Biological Engineering
关于 加州理工学院
Caltech is a world-renowned science and engineering research and education institution, where extraordinary faculty and students seek answers to complex questions, discover new knowledge, lead innovation, and transform our future. Caltech's mission is to expand human knowledge and benefit society through research integrated with education. We investigate the most challenging, fundamental problems in science and technology in a singularly collegial, interdisciplinary atmosphere, while educating outstanding students to become creative members of society.
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