课程信息
4.7
632 个评分
154 个审阅

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完成时间大约为15 小时

建议:20 hours of videos and quizzes...

英语(English)

字幕:英语(English)

您将获得的技能

BiologyMicrobiologyPublic HealthVaccine Development

100% 在线

立即开始,按照自己的计划学习。

可灵活调整截止日期

根据您的日程表重置截止日期。

完成时间大约为15 小时

建议:20 hours of videos and quizzes...

英语(English)

字幕:英语(English)

教学大纲 - 您将从这门课程中学到什么

1
完成时间为 1 小时

Course Introduction

Welcome to Epidemics: the Dynamics of Infectious Diseases. This course will teach you about the variety of parasitic organisms that infect humans, animals, and plants, how these parasites spread through populations, and the various methods that we employ to control them....
3 个阅读材料
3 个阅读材料
Course Overview10分钟
Course Syllabus10分钟
Glossary of Terms10分钟
完成时间为 1 小时

Pathogens

In the first module, you will learn about the organisms that can infect us and make us sick: pathogens. We will first take a look at the various types of pathogens that exist, and then learn about what it means to be infectious, and what it means to cause disease. After that, we will cover the various methods by which pathogens can transmit from one person to the next, thereby causing an epidemic. You will learn about the most important number in all of epidemiology, R0, and why this number is so important. Finally, we will learn that microorganisms are not always harmful, but can be beneficial to us as well....
7 个视频 (总计 40 分钟), 1 个阅读材料, 1 个测验
7 个视频
Micro and Macro Parasites5分钟
Infection and Disease6分钟
Transmission Types4分钟
Reproductive Number4分钟
Epidemic Curve6分钟
Micro-organisms6分钟
1 个阅读材料
Module Overview10分钟
1 个练习
Summative: Pathogens20分钟
2
完成时间为 1 小时

Hosts

The second module of the course covers host factors that determine the outcome of infection. We will first focus on host immunity and present both the general immune capabilities—the innate immune response—that are encoded in our genes and that provide the initial response to infection and the adaptive immune response, which arises from highly specialized cells that protect against a specific pathogen. You will then learn about the ways that pathogens circumvent these two types of immunity and consider other factors that can contribute to an individual becoming infected or diseased—including genetic factors, other microbes, and how social and emotional factors influence immunity. We will then consider how infection with a microorganism causes disease and how public health officials determine whether a disease outbreak is caused by an infectious organism....
7 个视频 (总计 41 分钟), 1 个阅读材料, 1 个测验
7 个视频
Types of Immunity: Adaptive Immune System5分钟
Immune Evasion6分钟
Other Determinants of Susceptibility6分钟
Social Influences on Immunity4分钟
Pathogens and Disease6分钟
Detecting an Infectious Disease Outbreak6分钟
1 个阅读材料
Module Overview: Hosts10分钟
1 个练习
Summative: Hosts20分钟
3
完成时间为 1 小时

Basics of Ecology

The third module of the course covers ecological factors that influence the dynamic patterns of infectious disease. We will discuss the conditions under which a pathogen can drive its host to extinction. We will look at how the demography of the host may allow the pathogen to persist in some populations but not others. We will talk about how host and pathogen characteristics interact to shape different temporal patterns of disease incidence at the population level and discuss the ecological consequences of infecting more than one host species....
9 个视频 (总计 55 分钟), 1 个阅读材料, 1 个测验
9 个视频
Force of Infection5分钟
Cycles4分钟
Seasonality3分钟
Flu 19185分钟
Host Diversity, Host Range3分钟
Critical Community Size8分钟
Pathogen-Microbiome Interactions8分钟
The 2014 Ebola Outbreak9分钟
1 个阅读材料
Module Overview: Basics of Ecology10分钟
1 个练习
Summative: Basics of Ecology20分钟
4
完成时间为 1 小时

Epidemiology

Where humans live and how they are connected to each other, have strong effects on how infectious diseases can spread. In this module, you will learn about some of the related key concepts of epidemiology. After looking at some fascinating history, we’ll learn about social networks as the ultimate “road map” on which diseases can travel and we’ll talk about how the structure of the network can influence disease dynamics. After that, we’ll cover three topics that all affect infectious disease epidemiology in dramatic ways: human transport systems, population density and so-called superspreaders - individuals who can spread a disease to dozens or even hundreds of other individuals. We’ll close by identifying what information is required for disease surveillance....
8 个视频 (总计 52 分钟), 1 个阅读材料, 1 个测验
8 个视频
Social Networks5分钟
Structure of Networks5分钟
Superspreaders6分钟
Spatial Hetergeneity5分钟
Movement and Modern Transportation5分钟
Surveillance and Disclosure5分钟
Co-Infection Consequences10分钟
1 个阅读材料
Module Overview: Epidemiology10分钟
1 个练习
Summative: Epidemiology20分钟
5
完成时间为 1 小时

Vaccination

In module 5 of the course, you will learn about vaccination, one of the most common approaches to the prevention of epidemics. We'll first put vaccination in the context of the many types of public health interventions that that can be used to prevent or treat disease. After that you will learn about the development of the first vaccine, how vaccines work to prevent infection, and the impact that vaccination has had on the prevention of disease worldwide. After that, you will learn about how vaccination can provide protection to everyone, even the unvaccinated, in the population through "herd immunity" and how we can use the structure of social networks within populations to more efficiently achieve this herd protection. Finally we'll learn about how individuals choices about whether or not to get vaccinated can lead to impacts across the whole of the population....
7 个视频 (总计 40 分钟), 1 个阅读材料, 1 个测验
7 个视频
Discovery of the First Vaccine3分钟
Global Impact of Vaccination6分钟
How Vaccination Works7分钟
Herd Immunity5分钟
Social Networks and Targeted Vaccination6分钟
Vaccination Refusal5分钟
1 个阅读材料
Module Overview: Vaccination10分钟
1 个练习
Summative: Vaccination20分钟
6
完成时间为 2 小时

Control Mechanisms

In module 6 of the course, you will learn about mechanisms involved in controlling epidemics. In these lectures, we will discuss what control mechanisms are trying to do, such as breaking the chain of transmission, and many ways by which animals and humans attempt to achieve control. These means include pharmaceutical and non-pharmaceutical interventions, appearing at individual or population levels. We will describe examples of great successes in eradication, and the reasons why control efforts fail....
10 个视频 (总计 63 分钟), 1 个阅读材料, 1 个测验
10 个视频
Social Challenges to Eradication4分钟
Non-pharmaceutical Interventions: Animals5分钟
Non-pharmaceutical Interventions: Humans 14分钟
Non-pharmaceutical Interventions: Humans 27分钟
Behavioral Avoidance6分钟
Controlling the Vector8分钟
Consequences of Control7分钟
Vaccination Ethics7分钟
New Approaches to an Old Infection5分钟
1 个阅读材料
Module Objectives: Control Mechanisms10分钟
1 个练习
Summative: Control Mechanisms20分钟
7
完成时间为 1 小时

Emergence

In module 7 of the course, we’ll look at so-called emerging infectious diseases. These are diseases that are causing new problems. They include infectious agents that are new to humanity, but also infectious agents that were once controlled and are now returning, particularly those that are evolving around formerly very effective public health tools like drugs and vaccines. This means much of the week involves a discussion of evolution. We will look at these emerging diseases and ask, where do they come from and what can be done about them? You will learn about new ideas for managing evolution, and some of the societal challenges involved. We will also look at the related question of how some diseases evolve to be nicer or nastier to their hosts....
7 个视频 (总计 49 分钟), 1 个阅读材料, 1 个测验
7 个视频
Re-emergence5分钟
Evolution General5分钟
Antibiotic and Drug Resistance5分钟
Management of Resistance8分钟
Behavioral And Economic Impact5分钟
Evolution of Virulence8分钟
1 个阅读材料
Module Overview: Emergence10分钟
1 个练习
Summative: Emergence20分钟
8
完成时间为 1 小时

Global Health

In this final module we explore the global context of epidemics. The world is rapidly changing with the global population increasing and the speed of travel and extent of globalization piling on the pressure of infectious diseases. In this week we set out first to explore a textbook example of disease shaped by the conditions presented by modern living: the disease SARS. We will see how high density living in cities coupled with links to wildlife diseases through markets can create a pandemic. We then explore traditional methods of disease surveillance and then more recent ones afforded to us by the web and networks made possible through google, twitter and other social media. Important to this global view is human behavior, our evolving culture and health. We will also consider emerging disease and the global pattern of diseases across our recent history and how from our earliest beginnings of global travellers we have affected the spread of diseases. Finally, we discuss disease of our food plants and how models of disease spread are developed to promote better global health. As a postscript to the course we ask the questions, so beloved of modern media, could we become zombies?...
9 个视频 (总计 55 分钟), 1 个阅读材料, 1 个测验
9 个视频
Disease Surveillance - Classical7分钟
Disease Surveillance - Digital5分钟
Culture and Health5分钟
Emerging Disease Issues7分钟
Crop Diseases and Food Security5分钟
Global Pattern of Parasite Biodiversity4分钟
Models of Infectious Diseases7分钟
Zombies6分钟
1 个阅读材料
Module Overview: Global Health10分钟
1 个练习
Summative: Global Health20分钟
完成时间为 4 小时

Ask Us Anything Videos

The videos accessible in this module are responses to questions that have been posed in previous sessions of this course. We invite you to look around here as an additional resource to answer questions you might have yourself or explore topics that pique your interest. ...
36 个视频 (总计 261 分钟)
36 个视频
What Does It Mean to Be Infectious?4分钟
What is the Impact of Prior Infections on Susceptibility to New Pathogens?5分钟
What Ended the Plague? What Can We Learn About Pandemics?5分钟
Can Behavior Contribute to Susceptibility?6分钟
Marilyn Roosinck and What’s Different about Plant Epidemiology?8分钟
Can Plants be Vectors of Disease?4分钟
What are Other Determinants of Susceptibility?5分钟
Can Pathogens Change Host Function?5分钟
Immune System Conflict6分钟
Eric Harvill and What is the Whole Micro-Biome, Pro-Biotic, Good Bacteria Thing?6分钟
Why Can't Our Antibodies Mutate Like Antigens?4分钟
How Does Microbiome Exchange Therapy Work?8分钟
What are the Best Strategies to Combat Multi-Species Infections?7分钟
How Relevant is the Concept of Critical Community Size?7分钟
Isabella Catadori and the Translation of Her Lab Work into the Field5分钟
Examples of Co-Infections and How They Change Epidemiology of Human Infections6分钟
Super-Shedders v. Super Spreaders and the Pareto Principle6分钟
The Role of Social Media in Epidemiology and how Information is Disseminated8分钟
Dr. Vivek Kapur and What Do We Need to Know about Development and Implementation of New Vaccines?9分钟
Why Don't We Have Vaccines for Everything?8分钟
Why Don't We Use Targeted Vaccinations?7分钟
What Are the Benefits of So-Called Gain-of-Function Experiments?11分钟
Dr. Moriah Szpara and How/Why do viruses like Varicella and Herpes Re-activate Themselves?7分钟
What are the Challenges to the Eradication of Pathogens and Setting Eradication as a Goal?6分钟
How Does Stress Affect Susceptibility and the Expression of Disease?6分钟
Has there been a Collective Change in Human Behavior in Response to Sexually Transmitted Diseases?9分钟
What can we do to minimize selection for resistance in vectors?8分钟
Genetic engineering of vectors? pt.17分钟
Genetic engineering of vectors? pt.27分钟
What is the role of climate change in disease emergence?8分钟
What can we learn from antibiotic and vaccine use in agriculture? 7分钟
Dr. Craig Cameron and What do We Mean by 'Antivirals?'8分钟
What is it About Polio?9分钟
What About the One Health Concept?7分钟
What is the Next Big Thing?8分钟
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创建者 DBApr 23rd 2016

Can't fault this course at all and nor would I want to. Very interesting, brilliantly presented and the range of experts really enhanced it. It was engaging and made me keen to find out more.

创建者 DJMay 13th 2017

It is a wonderful course , I have gain and updated my Knowledge in the area of Epidemics and Infectious Disease, Thanks to the Course organizers and most effective presentations . Dr Shivaji

讲师

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Dr. Ottar N. Bjornstad

Professor of Entomology and Biology
Department of Biology
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Dr. Rachel A. Smith

Associate Professor
Department of Communication Arts & Sciences and Human Development & Family Studies
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Dr. Mary L. Poss

Professor of Biology
Department of Biology
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Dr. David P. Hughes

Assistant Professor of Entomology and Biology
Department of Biology
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Dr. Peter Hudson

Willaman Professor of Biology
Department of Biology
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Dr. Matthew Ferrari

Assistant Professor of Biology
Department of Biology
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Dr. Andrew Read

Alumni Professor in the Biological Sciences, and Professor of Entomology
Center for Infectious Disease Dynamics
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Dr. Marcel Salathé

Assistant Professor of Biology
Department of Biology

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