课程信息
4.5
31 ratings
7 reviews
Most people know that electrically active cells in nerves, in the heart and in the brain generate electrical currents, and that somehow these result in measurements we all have heard about, such as the electrocardiogram. But how? That is, what is it that happens within the electrically active tissue that leads to the creation of currents and voltages in their surroundings that reflect the excitation sequences timing, and condition of the underlying tissue. This course explores that topic. Rather than being a primer on how to interpret waveforms of any kind in terms of normality or disease, the goal here is to provide insight into how the mechanism of origin actually works, and to do so with simple examples that are readily pictured with simple sketches and one’s imagination, and then moving forward into comparison with experiments and finding outcomes quantitatively....
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Intermediate Level

中级

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建议:7 weeks of study, 1-3 hours/week

完成时间大约为6 小时
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English

字幕:English
Globe

100% 在线课程

立即开始,按照自己的计划学习。
Calendar

可灵活调整截止日期

根据您的日程表重置截止日期。
Intermediate Level

中级

Clock

建议:7 weeks of study, 1-3 hours/week

完成时间大约为6 小时
Comment Dots

English

字幕:English

教学大纲 - 您将从这门课程中学到什么

1

章节
Clock
完成时间为 1 小时

Week 1

A brief history of extracellular measurements, and an example of such a recording. The goal is to understand the amplitudes and time variation of such measurements, as well as learn about some interesting and useful historical events....
Reading
3 个视频(共 20 分钟), 3 个阅读材料, 1 个测验
Video3 个视频
Welcome7分钟
The First Extracellular Measurements5分钟
Observing Wave Forms Between Human Hands7分钟
Reading3 个阅读材料
Course Overview10分钟
Assessments, Grading and Certificates10分钟
Week 1 Slides10分钟
Quiz1 个练习
120分钟

2

章节
Clock
完成时间为 2 小时

Week 2

A presentation of the cylindrical fiber model of a nerve. The goal is to see how this geometrically simple model of a nerve actually is sufficient to explain complex bioelectric events within and around electrically active tissue. One learns that currents are driven forward by voltages across cell membranes,. Current loops are created, with some parts of the current loop inside and other parts outside the active cells. Electrical potentials are created by the current loops, and are positive when these are approaching, negative when they are receding. In so doing they form the basis of all extracellular wave forms....
Reading
9 个视频(共 44 分钟), 3 个阅读材料, 1 个测验
Video9 个视频
Geometry6分钟
Left or right side stimulation5分钟
Simultaneous stimulation model2分钟
Definitions and questions6分钟
Origin in the membrane6分钟
Big loops as well as small4分钟
Approaching wave forms5分钟
Departing wave forms3分钟
Observations4分钟
Reading3 个阅读材料
Cylinderical Fiber Model Slides9分钟
Current Loops Slides10分钟
Current Loops and the Extracellular Waveforms Slides10分钟
Quiz1 个练习
224分钟

3

章节
Clock
完成时间为 1 小时

Week 3

Notable and useful aspects of extracellular wave forms are their changes in shape. What causes such changes? Two illuminating examples are studied, one that does not, and then another that does....
Reading
7 个视频(共 33 分钟), 3 个阅读材料, 1 个测验
Video7 个视频
Vm and current inside3分钟
Vm patterns3分钟
Current loops3分钟
Experimental setup, cardiac Purkinje6分钟
Stimulation at the left or right3分钟
Stimulation at both ends, collision5分钟
Reading3 个阅读材料
When do Wave Shapes Change? Slides10分钟
Simultaneous Left and Right Stimulation Slides10分钟
Experimental Data Slides10分钟
Quiz1 个练习
324分钟

4

章节
Clock
完成时间为 1 小时

Week 4

Weeks 1 to 3 present some intriguing concepts and explain them with drawings and sketches. Do the wave forms so drawn have any connection with real tissue? Indeed they do. The goal of this week is to examine some specific experimental wave forms that were measured in cardiac Punkinje fibers, and to compare them those anticipated in earlier weeks.Week 4 is the end of the standard course. The remaining weeks are for honors study....
Reading
4 个视频(共 17 分钟), 1 个阅读材料, 1 个测验
Video4 个视频
Two-fiber model, asynchronous2分钟
Experimental findings6分钟
Multiphasic summary3分钟
Reading1 个阅读材料
Multiphasic Recordings Slides10分钟
Quiz1 个练习
424分钟
4.5

热门审阅

创建者 AJApr 15th 2018

Great follow up course to the previous within the installment regarding bioelectricity. Taught me quite a lot and am looking forward to further releases to the series if they are in the works.

创建者 PWMar 8th 2017

Having been out school for over 30 years this was a very challenging but rewarding course for myself. I'm glad i took it

讲师

Dr. Roger Barr

Anderson-Rupp Professor of Biomedical Engineering and Associate Professor of Pediatrics
Biomedical Engineering, Pediatrics

关于 Duke University

Duke University has about 13,000 undergraduate and graduate students and a world-class faculty helping to expand the frontiers of knowledge. The university has a strong commitment to applying knowledge in service to society, both near its North Carolina campus and around the world....

常见问题

  • Once you enroll for a Certificate, you’ll have access to all videos, quizzes, and programming assignments (if applicable). Peer review assignments can only be submitted and reviewed once your session has begun. If you choose to explore the course without purchasing, you may not be able to access certain assignments.

  • When you purchase a Certificate you get access to all course materials, including graded assignments. Upon completing the course, your electronic Certificate will be added to your Accomplishments page - from there, you can print your Certificate or add it to your LinkedIn profile. If you only want to read and view the course content, you can audit the course for free.

  • No. Completion of a Coursera course does not earn you academic credit from Duke; therefore, Duke is not able to provide you with a university transcript. However, your electronic Certificate will be added to your Accomplishments page - from there, you can print your Certificate or add it to your LinkedIn profile.

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