Synbio is a diverse field with diverse applications, and the different contexts (e.g., gain-of-function research, biofuels) raise different ethical and governance challenges. The objective of this course is to increase learners’ awareness and understanding of ethical and policy/governance issues that arise in the design, conduct and application of synthetic biology. The course will begin with a short history of recombinant DNA technology and how governance of that science developed and evolved, and progress through a series of areas of application of synbio.
生命工程：合成生物、生物伦理与公共政策
约翰霍普金斯大学课程信息
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中级
完成时间大约为13 小时
英语（English）
字幕：英语（English）
学生职业成果
33%
通过此课程获得实实在在的工作福利
可分享的证书
完成后获得证书
100% 在线
立即开始，按照自己的计划学习。
可灵活调整截止日期
根据您的日程表重置截止日期。
中级
完成时间大约为13 小时
英语（English）
字幕：英语（English）
提供方
约翰霍普金斯大学
The mission of The Johns Hopkins University is to educate its students and cultivate their capacity for life-long learning, to foster independent and original research, and to bring the benefits of discovery to the world.
教学大纲 - 您将从这门课程中学到什么
完成时间为 18 分钟
Welcome to Engineering Life: SynBio, Bioethics & Public Policy
完成时间为 18 分钟
1 个视频 （总计 3 分钟）, 1 个阅读材料
1 个视频
1 个阅读材料
Syllabus: Engineering Life10分钟
完成时间为 2 小时
Recombinant DNA Technology: Science and History
We start the course by learning a bit about the history and context of the development of recombinant DNA (rDNA) technology in the 1970s, the ethics and policy issues raised by that science, and how those issues remain with us today in synthetic biology. The work of the week includes lecture videos, readings, and an interview with LeRoy Walters, who was involved in the discussions and debates about rDNA in its early years. The week will conclude with a quiz.
完成时间为 2 小时
8 个视频 （总计 105 分钟）, 1 个阅读材料, 1 个测验
8 个视频
A Brief History of rDNA15分钟
A Brief History of Asilomar & the RAC19分钟
Interview: Dr. LeRoy Walters (Part 1)19分钟
Interview: Dr. LeRoy Walters (Part 2)21分钟
Interview: Dr. LeRoy Walters (Part 3)12分钟
Relevant Contemporary Policy Context5分钟
The Emergence of SynBio9分钟
1 个阅读材料
Week 1 Readings10分钟
1 个练习
Week 1 Quiz30分钟
完成时间为 2 小时
GOF Research
In Week 2 we will learn about and discuss gain of function (GOF) research and the dual-use concerns raised by synthetic biology. The work of the week includes lecture videos, a number of outside videos, and readings. The assessment this week will be your first peer-assessed project, and will focus on identifying ethical duties related to GOF research policy.
完成时间为 2 小时
6 个视频 （总计 49 分钟）, 2 个阅读材料, 1 个测验
6 个视频
Gain of Function Research5分钟
Dual Use Research9分钟
GOF Research Case Study: H5N112分钟
Ethical Issues Raised by GOF Research11分钟
Governance and GOF Research9分钟
2 个阅读材料
Week 2 Readings10分钟
Additional Video Content10分钟
完成时间为 2 小时
Biofuels
This week, we’ll learn about biofuels, the complex task of balancing the many ethical issues they raise, and the role of synthetic biology in biofuels development. The work of the week includes lecture videos, one outside video, readings, and an interview with Deborah Scott about biofuels governance. The week will conclude with a quiz.
完成时间为 2 小时
7 个视频 （总计 69 分钟）, 2 个阅读材料, 1 个测验
7 个视频
Biofuels9分钟
Applications5分钟
Case Study4分钟
Ethical Issues Raised by SynBio-based Biofuels8分钟
Interview: Deborah Scott, PhD, JD (Part 1)24分钟
Interview: Deborah Scott, PhD, JD (Part 2)14分钟
2 个阅读材料
Week 3 Readings10分钟
Additional Video Content10分钟
1 个练习
Week 3 Quiz30分钟
完成时间为 2 小时
Human Health
This week we will learn a bit about applications of synthetic biology to human health, and the ethics of human subjects research. The work of the week includes lecture videos, one outside video, and readings. The assessment this week will be your second peer-assessed project, and will build on your first project, from Week 2. This project will focus on identifying stakeholders in a policy decision, their interests in the decision, and the related ethical duties of the decision-maker.
完成时间为 2 小时
7 个视频 （总计 50 分钟）, 2 个阅读材料, 1 个测验
7 个视频
Synbio in Human Health5分钟
Human Genetic Modification6分钟
Case Study: Artemisinin6分钟
Case Study: GM Mosquitos8分钟
Ethical Issues Raised by SynBio-based Medical Applications13分钟
Governance of SynBio-based Medical Applications7分钟
2 个阅读材料
Week 4 Readings10分钟
Additional Video Content10分钟
审阅
来自生命工程：合成生物、生物伦理与公共政策的热门评论
由 JQ 提供Jul 27, 2017
fun and interesting course. very well taught by somebody obviously knowledgeable. Thanks so much.
由 TN 提供Jun 15, 2017
Highly thought-provoking. One of the most interesting classes I have taken on Coursera.
由 JS 提供Nov 6, 2019
pretty good class. kind of technical but gives one some good stuff to think about
由 AN 提供Sep 11, 2018
Dr. Matthews is a fantastic instructor; Slide deck is great.
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Is financial aid available?
是的，Coursera 可以向无法承担学费的学生提供助学金。点击左侧‘注册’按钮下的‘助学金’链接即可申请助学金。您可以根据屏幕提示完成申请，申请获批后会收到通知。了解详情。
What is the most important thing I'll learn if I take this class?
The primary goal of this class is to help scientists think a bit more like policy makers and the public, seeing not only the incredible promise of the science they do, but also the potential risks and pitfalls, so these can be avoided or designed against at the beginning of a project, rather than at the end, when the challenges and costs are higher. Working with scholars, policy makers, and fellow learners, students will gain a greater understanding and appreciation of the ethics and governance of synthetic biology.
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