Improving health and healthcare institutions requires understanding of data and creation of interventions at the many levels at which health IT interact and affect the institution. These levels range from the external “world” in which the institution operates down to the specific technologies. Data scientists find that, when they aim at implementing their models in practice, it is the “socio” components that are both novel to them and mission critical to success. At the end of this course, students will be able to make a quick assessment of a health informatics problem—or a proposed solution—and to determine what is missing and what more needs to be learned.