This course familiarizes students with the novel concepts being used to revamp regulatory toxicology in response to a breakthrough National Research Council Report “Toxicity Testing in the 21st Century: A Vision and a Strategy.” We present the latest developments in the field of toxicology—the shift from animal testing toward human relevant, high content, high-throughput integrative testing strategies. Active programs from EPA, NIH, and the global scientific community illustrate the dynamics of safety sciences.
教学大纲 - 您将从这门课程中学到什么
周
1完成时间为 3 小时
Module 1
This model will give you a broad introduction to the Toxicology 21st century (Tox21c) field and familiarize you with the main document, which summarize the main ideas and principles of Tox21c.
10 个视频 （总计 121 分钟）, 3 个阅读材料, 1 个测验
10 个视频
Course Introduction16分钟
Introduction49
Center for Alternatives to Animal Testing4分钟
Toxicology of the Fifteenth to Twentieth Centuries15分钟
Toxicology for the Twenty-First Century15分钟
Historical Perspective17分钟
The First Report: Toxicity Testing for Assessment of Environmental Agents11分钟
The Second Report: Toxicity Testing in the 21st Century: A Vision and A Strategy Vision and Its Components22分钟
The Second Report: Toxicity Testing in the 21st Century: A vision and A Strategy Implementation13分钟
3 个阅读材料
useful links20分钟
supporting reading material10分钟
Supporting reading material10分钟
1 个练习
Module 1 Quiz10分钟
周
2完成时间为 5 小时
Module 2
This module will discuss how ToxCast and Tox21 technologies can be used in practice. The US EPA Endocrine Disruptor Screening Program will be discussed in detail and we will demonstrate how the ToxCast platform replaced in vivo tiered approaches in EDSP and, thus, acelerate the process of . In the second lesson of this module, the development of in silico models for toxicity testing will be discussed.
10 个视频 （总计 119 分钟）, 4 个阅读材料, 2 个测验
10 个视频
Adverse Outcome Pathways (AOPs)10分钟
Exposure-Based Chemical Prioritization13分钟
ER Bioactivity Model16分钟
US EPA Endocrine Disruptor Screening Program (EDSP)17分钟
Modeling of Hazard and Organ Manifestation11分钟
Building a Signature for Vascular Disruption10分钟
Testing the Vascular Disruption Signature8分钟
Virtual Tissue Model: Vascular Development12分钟
Functional Vascular Development Assays16分钟
4 个阅读材料
Supporting Reading Material10分钟
Useful links10分钟
Supporting Reading Material10分钟
Useful links10分钟
1 个练习
Module 2 Quiz8分钟
周
3完成时间为 3 小时
Module 3
This module will familiarize you with the Human Toxome Project run by Johns Hopkins University in collaboration with several university, industry, and research agencies. Omics technologies, their advantages and disadvantages, as well as concepts of Adverse Outcome Pathways (AOP) and Pathways of Toxicity (PoT) will be discussed.
11 个视频 （总计 126 分钟）, 2 个阅读材料, 1 个测验
11 个视频
Mechanistic Toxicology and Pathway Mapping at the Basics of 21st Century Toxicology16分钟
The Concept of the Human Toxome Project21分钟
Concept and Tool Devlopment11分钟
Progress7分钟
Conclusions and Prospectives8分钟
Introduction - What Is a Pathway of Toxicity, and Why Do We Need Them?6分钟
Omics Technologies and High-Throughput Data11分钟
Interpreting Omics Data11分钟
PoT Examples and Conclusions15分钟
Pathways of Toxicity and Adverse Outcome Pathways (AOPs)13分钟
2 个阅读材料
Supporting reading materials10分钟
Supporting reading material10分钟
1 个练习
Module 3 Quiz8分钟
周
4完成时间为 4 小时
Module 4
The first lesson in this module will explain the concept of read-across, why it is important for regulatory risk assessment, and how it can be implemented by industry in response to REACH legislation. The organotypic cultures lesson will teach you about existing in vitro cell-based models starting from simple monolayer cultures of cell lines and ending with complex combined organ-on-a-chip and human-on-a-chip approaches.
15 个视频 （总计 148 分钟）, 3 个阅读材料, 2 个测验
15 个视频
The Concept of Toxicological (Biological) Pathways, e.g., “Adverse Outcome Pathways,” Is the Basis of Predictive Toxicology5分钟
Introduction to the OECD AOP Framework10分钟
Building, Evaluating, and Using AOPs in Safety Decisions6分钟
Online Tools Available to Everyone, Including an Online AOP Course4分钟
Welcome to Module 42分钟
Introduction to Read-Across18分钟
Good Read-Across Practice21分钟
Supporting Read-Across with Biological Data12分钟
Creating a Database of Toxicity12分钟
Creating an Automated Tool for Read-Across9分钟
Paradigm Shift in Toxicology7分钟
2D In Vitro Cell Culture8分钟
3D In Vitro Cell Cultures8分钟
Organ-on-a-Chip11分钟
3 个阅读材料
Supporting reading material10分钟
Supporting reading material10分钟
Useful links10分钟
2 个练习
Module 4 Quiz8分钟
Mid-term exam44分钟
完成时间为 1 小时
Module 5
This module will teach you the role of miRNA and epigenetics in toxicology and environmental health.
6 个视频 （总计 41 分钟）, 1 个阅读材料, 1 个测验
6 个视频
MicroRNA and Epigenetics4分钟
Epigenetics and Environment6分钟
MicroRNA: Biogenesis and Functions11分钟
Role of MicroRNA in Development6分钟
MicroRNA in Toxicology9分钟
1 个阅读材料
Supporting reading material10分钟
1 个练习
Module 5 Quiz8分钟
4.5
5 个审阅热门审阅
Very nicely designed course. The instructors offer an excellent and easy to understand overview of a range of promising Tox21 tools and approaches using good examples and illustrations.
A very well-taught course with lots of useful information. I highly recommend it.
讲师
Lena Smirnova
Research AssociateCenter for Alternatives to Animal Testing
Thomas Hartung
ProfessorEnvironmental Health and Engineering
关于 约翰霍普金斯大学
The mission of The Johns Hopkins University is to educate its students and cultivate their capacity for life-long learning, to foster independent and original research, and to bring the benefits of discovery to the world.
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