This course aims to help you to ask better statistical questions when performing empirical research. We will discuss how to design informative studies, both when your predictions are correct, as when your predictions are wrong. We will question norms, and reflect on how we can improve research practices to ask more interesting questions. In practical hands on assignments you will learn techniques and tools that can be immediately implemented in your own research, such as thinking about the smallest effect size you are interested in, justifying your sample size, evaluate findings in the literature while keeping publication bias into account, performing a meta-analysis, and making your analyses computationally reproducible. If you have the time, it is recommended that you complete my course 'Improving Your Statistical Inferences' before enrolling in this course, although this course is completely self-contained.