A welcome message from Dr. Roden

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来自 Vanderbilt University 的课程

Case Studies in Personalized Medicine

138 个评分

Vanderbilt University

Case Studies in Personalized Medicine

138 个评分

Learn how advances in biomedicine hold the potential to revolutionize drug development, drug treatments, and disease prevention: where are we now, and what does the future hold? This course will present short primers in genetics and mechanisms underlying variability in drug responses. A series of case studies will be used to illustrate principles of how genetics are being brought to bear on refining diagnoses and on personalizing treatment in rare and common diseases. The ethical and operational issues around how to implement large scale genomic sequencing in clinical practice will be addressed. After completing this course, learners will understand 1. The ways in which genetic variants can contribute to human disease susceptibility 2. How to choose among drug therapies based on genetic factors 3. That the functional consequences of the vast majority of genetic variants discovered by modern sequencing are unknown. This course is targeted primarily at physicians 5+ years out of training. Other healthcare providers, medical/health sciences students, and members of the public may also be interested. Course launches January 15, 2016. * The information presented in “Case Studies in Personalized Medicine” is offered for educational and informational purposes only, and should not be construed as personal medical advice. If you have questions or concerns about a medical matter, please consult your doctor or other professional healthcare provider.

从本节课中

UNIT 1: INTRODUCTION TO PERSONALIZED MEDICINE

The first module of this course will focus on introducing the concept of personalized medicine. We will very briefly review fundamentals of genetics as these apply to personalized medicine (DNA structure; RNA; protein structures; function of DNA; coding; DNA variations; types of genetic variants), as well as review statistical concepts and skills important to clinical data analysis (odds ratios, relative risk, P values, multiple testing, sensitivity, specificity, ROCs). In Module 2 we will explore drug actions and reactions as we look closely at the general mechanisms underlying variability in drug responses, drug metabolism and transport, and genetic variability in drug-handling molecules.

A welcome message from Dr. Roden3:28

与讲师见面

Dan Roden, M.D.
Professor of Medicine and Pharmacology
Assistant Vice Chancellor for Personalized Medicine

[MUSIC]

Hi, I'm Dan Rhoden and welcome to this course on personalized medicine.

[MUSIC]

I'm a faculty member at Vanderbilt University Medical Center where I've spent

the last three plus decades as an investigator and as a physician.

Here at Vanderbilt, we made an institutional commitment to the concept of

personalized medicine, largely around the genetics of variable drug response,

although that vision is now expanding into disease susceptibility as well.

We made that commitment about ten years ago.

Part of the reason we made that commitment is because of the long standing tradition

of excellence in clinical pharmacology.

Another part of that reason is the longstanding commitment to information

science, and particularly to the way in which we use varied information across

many, many genes, and couple that to the electronic medical record.

Something that we'll talk about in this course.

The reason that I'm teaching this course is that I think we've

seen an explosion In our understanding of

the concepts of personalized medicine over the last decade.

That explosion has come along with the ability to sequence patients

and generate large volumes of genetic data, as well as our

understanding of the way in which genes affect our disease susceptibility.

Many patients come to us for many conditions, and they take many,

many different medicines, and

the potential for interaction across diseases and across drugs is great.

And so the idea is a personalized medicine is to do the best we can based on

the evidence that we have, be it from genetics or be it from large clinical

trials to deliver the best of individual loss care for that patient.

[MUSIC]

The main target audience for

this course are physicians who have been in practice for five or more years.

Those physicians are increasingly exposed to the concepts of personalized medicine,

and genomic base personalized medicine.

But don't have the medical school background that enables them to critically

look at the literature and understand when it is important to apply that information.

And when it may not yet be important to apply that information.

Now that's the main target audience but of course, other physicians,

medical students, other healthcare professionals, undergraduate students,

interested members of the life public are all welcome to take the course.

There will be a couple of introductory,

modules around the fundamental principles of personalized medicine.

The history of personalized medicine, the history of genetics.

But the majority of the course are modules based on individual cases and

individual examples that highlight specific genetic variance that may

be important, or are important for the care of individual patients.

And we'll end the course by some modules looking towards the future.

The course itself will be a total of six weeks.

There will be quizzes.

There will be discussions.

And there will be a final project at the end of the course.

So welcome to this course on Personalized Medicine.

I look forward to having you participate in this course,

and hope that you get something great out of it.

Thank you.

[MUSIC]

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