课程信息
4.7
197 个评分
39 个审阅

100% 在线

立即开始,按照自己的计划学习。

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初级

完成时间大约为11 小时

建议:12-18 hours of videos and labs...

英语(English)

字幕:英语(English)

100% 在线

立即开始,按照自己的计划学习。

可灵活调整截止日期

根据您的日程表重置截止日期。

初级

完成时间大约为11 小时

建议:12-18 hours of videos and labs...

英语(English)

字幕:英语(English)

教学大纲 - 您将从这门课程中学到什么

1
完成时间为 3 小时

Protein Motifs

In this module we'll be exploring conserved regions within protein families. Such regions can help us understand the biology of a sequence, in that they are likely important for biological function, and also be used to help ascribe function to sequences where we can't identify any homologs in the databases. There are various ways of describing the conserved regions from simple regular expressions to profiles to profile hidden Markov models (HMMs)....
4 个视频 (总计 34 分钟), 4 个阅读材料, 1 个测验
4 个视频
Lecture21分钟
Lab Discussion9分钟
Summary1分钟
4 个阅读材料
Acknowledgements10分钟
Course Logistics10分钟
Lecture Materials10分钟
Lab 1 -- Protein Domain, Motif and Profile Analysis30分钟
1 个练习
Lab 1 Quiz6分钟
2
完成时间为 2 小时

Protein-Protein Interactions

In this module we'll be exploring protein-protein interactions (PPIs). Protein-protein interactions are important as proteins don't act in isolation, and often an examination of the interaction partners (determined in an unbiased, perhaps high throughput way) of a given protein can tell us a lot about its biology. We'll talk about some different methods used to determine PPIs and go over their strengths and weaknesses. In the lab we'll use 3 different tools and two different databases to examine interaction partners of BRCA2, a protein that we examined in last module's lab. Finally, we'll touch on a "foundational" concept, Gene Ontology (GO) term enrichment analysis, to help us understand in an overview way the proteins interacting with our example....
4 个视频 (总计 37 分钟), 2 个阅读材料, 1 个测验
4 个视频
Lecture23分钟
Lab Discussion11分钟
Summary1分钟
2 个阅读材料
Lecture Materials10分钟
Lab 2 -- Protein-Protein Interactions30分钟
1 个练习
Lab 2 Quiz6分钟
3
完成时间为 2 小时

Protein Structure

The determination of a protein's tertiary structure in three dimensions can tell us a lot about the biology of that protein. In this module's mini-lecture, we'll talk about some different methods used to determine a protein's tertiary structure and cover the main database for protein structure data, the PDB. In the lab we'll explore the PDB and an online tool for searching for structural (as opposed to sequence) similarity, VAST. We'll then use a nice piece of stand-alone software, PyMOL, to explore several protein structures in more detail....
4 个视频 (总计 32 分钟), 2 个阅读材料, 1 个测验
4 个视频
Lecture13分钟
Lab Discussion16分钟
Summary1分钟
2 个阅读材料
Lecture Materials10分钟
Lab 3 -- Structural Bioinformatics30分钟
1 个练习
Lab 3 Quiz6分钟
4
完成时间为 10 分钟

Review: Protein Motifs, Protein-Protein Interactions, and Protein Structure

...
1 个测验
1 个练习
Quiz: Protein Motifs, Protein-Protein Interactions, and Protein Structure10分钟
4.7
39 个审阅Chevron Right

20%

完成这些课程后已开始新的职业生涯

25%

通过此课程获得实实在在的工作福利

11%

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热门审阅

创建者 RGApr 6th 2017

Gives the student real world exposure to the tools to study proteins gene regulation, etc. Instructor is involved and friendly. Highly recommended for someone who is interested in contemporary

创建者 NMJan 9th 2018

Hi Nicholas, Thank you so much for giving a lot of information. Bioinformatic Methods II was little difficult but understood after repeating the lad discussions. Thanks a lot.

讲师

Avatar

Nicholas James Provart

Professor
Cell & Systems Biology

关于 多伦多大学

Established in 1827, the University of Toronto is one of the world’s leading universities, renowned for its excellence in teaching, research, innovation and entrepreneurship, as well as its impact on economic prosperity and social well-being around the globe. ...

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