课程信息
4.8
470 ratings
107 reviews
Over 500,000 people in the United States and over 8 million people worldwide are dying from cancer every year. As people live longer, the incidence of cancer is rising worldwide, and the disease is expected to strike over 20 million people annually by 2030. Everyone has been, or will be touched by cancer in some way during their lifetime. Thanks to years of dedication and commitment to research we’ve made enormous advances in the prevention and treatment of cancer, But there is still a lot of work to be done. In this course, physicians and scientists at the Johns Hopkins School of Medicine explain how cancer spreads or metastasizes. We’ll describe the major theories of metastasis and then describe the biology behind the steps in metastasis. The course also describes the major organs targeted by metastasis and describes how metastases harm the patient....
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100% 在线课程

立即开始,按照自己的计划学习。
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Beginner Level

初级

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建议:3 weeks, 1.5 hours per week

完成时间大约为7 小时
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English

字幕:English

您将获得的技能

CancerMolecular BiologyCancer BiologyCancer Stem Cells
Globe

100% 在线课程

立即开始,按照自己的计划学习。
Calendar

可灵活调整截止日期

根据您的日程表重置截止日期。
Beginner Level

初级

Clock

建议:3 weeks, 1.5 hours per week

完成时间大约为7 小时
Comment Dots

English

字幕:English

教学大纲 - 您将从这门课程中学到什么

1

章节
Clock
完成时间为 1 小时

History and Overview of Metastasis

In this first module, we'll concentrate on the history and overview of metastasis and give you a flavor of how cancer is defined as well as some of the history surrounding how we began to understand metastasis. ...
Reading
5 个视频(共 18 分钟), 1 个测验
Video5 个视频
Introduction to History and Overview of Metastasis分钟
History and Overview of Metastasis4分钟
History of Metastasis Theory4分钟
Introduction to the Sequential Steps of Metastasis5分钟
Quiz1 个练习
History and Overview of Metastasis20分钟
Clock
完成时间为 1 小时

Primary Tumor Growth and Neoangiogenesis

In this module, we'll focus on uncontrolled cell division, which is a defining property of cancer, as well as mutation and neoangiogenesis and their roles in tumor formation. We'll also take a look at a primary tumor microenvironment and its component cell types. ...
Reading
5 个视频(共 36 分钟), 1 个测验
Video5 个视频
Tumor formation: Uncontrolled cell division12分钟
The role of mutations in primary tumor formation and evolution11分钟
Neoangiogenesis: new blood vessel formation in cancer5分钟
The primary tumor microenvironment: what else affects primary tumor growth?6分钟
Quiz1 个练习
Primary Tumor Growth and Neoangiogenesis24分钟

2

章节
Clock
完成时间为 1 小时

EMT / Invasion / Intravasation

During this module, we'll turn our attention to the next steps after the initial primary tumor formation, epithelial to mesenchymal transition of cancer cells, and local tumor invasion and intravasation into blood or lymph vessels....
Reading
4 个视频(共 18 分钟), 1 个测验
Video4 个视频
Epithelial-mesenchymal transition, invasion, and intravision9分钟
Local Tumor Invasion4分钟
Intravasation2分钟
Quiz1 个练习
Invasion and Intravasation14分钟
Clock
完成时间为 1 小时

Survival in the Circulation and Extravasation

We'll now take a close look at cancer survival within the circulation, the role of the circulatory system in metastasis, the genetic determinants of metastatic potential, signalling mechanisms, chemokines, the dock and lock hypothesis, and extravasation. ...
Reading
6 个视频(共 31 分钟), 1 个测验
Video6 个视频
Glossary of Terms2分钟
The Circulation4分钟
How cancer cells survive while in circulation4分钟
Becoming a circulating tumor cell (CTC) and evading immune detection10分钟
Homing to a new site in the body and extravasation8分钟
Quiz1 个练习
Survival in the Circulation and Extravasation24分钟

3

章节
Clock
完成时间为 1 小时

Dormancy and Secondary Tumor Growth

In this module, we'll focus on dormancy and secondary tumor growth and how they contribute to the lethality of cancer. ...
Reading
6 个视频(共 31 分钟), 1 个测验
Video6 个视频
Metastatic homing5分钟
Evidence for cancer dormancy4分钟
Cancer dormancy defined8分钟
Properties of dormant cancer cells6分钟
Secondary outgrowth4分钟
Quiz1 个练习
Dormancy and Secondary Tumor Growth20分钟
Clock
完成时间为 1 小时

Morbidity and Mortality Associated with Metastasis

In the previous modules, we've looked closely at the sequential steps of metastasis and some of the biology of how metastasis occurs. Now, we'll turn our attention to morbidity and mortality, or in other words, how cancer hurts and kills people....
Reading
4 个视频(共 27 分钟), 1 个测验
Video4 个视频
Distribution of Metastasis: Where do cancers spread?10分钟
Cancer Syndromes14分钟
Congratulations1分钟
Quiz1 个练习
Morbidity and Mortality Associated with Metastasis20分钟

讲师

Kenneth J. Pienta, M.D.

The Donald S. Coffey Professor of Urology
The James Buchanan Brady Urological Institute

Jelani Zarif

Prostate Cancer Researcher
The James Buchanan Brady Urological Institute

Sarah Amend

Prostate Cancer Researcher
The James Buchanan Brady Urological Institute

Haley Axelrod

Prostate Cancer Researcher
The James Buchanan Brady Urological Institute

Kenneth Valkenburg

Prostate Cancer Researcher
The James Buchanan Brady Urological Institute

关于 Johns Hopkins University

The mission of The Johns Hopkins University is to educate its students and cultivate their capacity for life-long learning, to foster independent and original research, and to bring the benefits of discovery to the world....

常见问题

  • Once you enroll for a Certificate, you’ll have access to all videos, quizzes, and programming assignments (if applicable). Peer review assignments can only be submitted and reviewed once your session has begun. If you choose to explore the course without purchasing, you may not be able to access certain assignments.

  • When you purchase a Certificate you get access to all course materials, including graded assignments. Upon completing the course, your electronic Certificate will be added to your Accomplishments page - from there, you can print your Certificate or add it to your LinkedIn profile. If you only want to read and view the course content, you can audit the course for free.

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