课程信息
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100% 在线

立即开始,按照自己的计划学习。

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初级

完成时间大约为7 小时

建议:3 weeks, 1.5 hours per week...

英语(English)

字幕:英语(English)

您将获得的技能

CancerMolecular BiologyCancer BiologyCancer Stem Cells

100% 在线

立即开始,按照自己的计划学习。

可灵活调整截止日期

根据您的日程表重置截止日期。

初级

完成时间大约为7 小时

建议:3 weeks, 1.5 hours per week...

英语(English)

字幕:英语(English)

教学大纲 - 您将从这门课程中学到什么

1
完成时间为 1 小时

History and Overview of Metastasis

In this first module, we'll concentrate on the history and overview of metastasis and give you a flavor of how cancer is defined as well as some of the history surrounding how we began to understand metastasis.

...
5 个视频 (总计 18 分钟), 1 个测验
5 个视频
Introduction to History and Overview of Metastasis48
History and Overview of Metastasis4分钟
History of Metastasis Theory4分钟
Introduction to the Sequential Steps of Metastasis5分钟
1 个练习
History and Overview of Metastasis20分钟
完成时间为 1 小时

Primary Tumor Growth and Neoangiogenesis

In this module, we'll focus on uncontrolled cell division, which is a defining property of cancer, as well as mutation and neoangiogenesis and their roles in tumor formation. We'll also take a look at a primary tumor microenvironment and its component cell types.

...
5 个视频 (总计 36 分钟), 1 个测验
5 个视频
Tumor formation: Uncontrolled cell division12分钟
The role of mutations in primary tumor formation and evolution11分钟
Neoangiogenesis: new blood vessel formation in cancer5分钟
The primary tumor microenvironment: what else affects primary tumor growth?6分钟
1 个练习
Primary Tumor Growth and Neoangiogenesis24分钟
2
完成时间为 1 小时

EMT / Invasion / Intravasation

During this module, we'll turn our attention to the next steps after the initial primary tumor formation, epithelial to mesenchymal transition of cancer cells, and local tumor invasion and intravasation into blood or lymph vessels.

...
4 个视频 (总计 18 分钟), 1 个测验
4 个视频
Epithelial-mesenchymal transition, invasion, and intravision9分钟
Local Tumor Invasion4分钟
Intravasation2分钟
1 个练习
Invasion and Intravasation14分钟
完成时间为 1 小时

Survival in the Circulation and Extravasation

We'll now take a close look at cancer survival within the circulation, the role of the circulatory system in metastasis, the genetic determinants of metastatic potential, signalling mechanisms, chemokines, the dock and lock hypothesis, and extravasation.

...
6 个视频 (总计 31 分钟), 1 个测验
6 个视频
Glossary of Terms2分钟
The Circulation4分钟
How cancer cells survive while in circulation4分钟
Becoming a circulating tumor cell (CTC) and evading immune detection10分钟
Homing to a new site in the body and extravasation8分钟
1 个练习
Survival in the Circulation and Extravasation24分钟
3
完成时间为 1 小时

Dormancy and Secondary Tumor Growth

In this module, we'll focus on dormancy and secondary tumor growth and how they contribute to the lethality of cancer.

...
6 个视频 (总计 31 分钟), 1 个测验
6 个视频
Metastatic homing5分钟
Evidence for cancer dormancy4分钟
Cancer dormancy defined8分钟
Properties of dormant cancer cells6分钟
Secondary outgrowth4分钟
1 个练习
Dormancy and Secondary Tumor Growth20分钟
完成时间为 1 小时

Morbidity and Mortality Associated with Metastasis

In the previous modules, we've looked closely at the sequential steps of metastasis and some of the biology of how metastasis occurs. Now, we'll turn our attention to morbidity and mortality, or in other words, how cancer hurts and kills people.

...
4 个视频 (总计 27 分钟), 1 个测验
4 个视频
Distribution of Metastasis: Where do cancers spread?10分钟
Cancer Syndromes14分钟
Congratulations1分钟
1 个练习
Morbidity and Mortality Associated with Metastasis20分钟
4.8
126 个审阅Chevron Right

50%

完成这些课程后已开始新的职业生涯

46%

通过此课程获得实实在在的工作福利

18%

加薪或升职

来自Understanding Cancer Metastasis的热门评论

创建者 RBFeb 9th 2017

Good course, but why researchers whant to hold/control cancer in a human and not rebuild the destroyed mechanisms of autoregul;ation by genetic engeneering for example? That would be true cure.

创建者 RWJun 4th 2018

It is a beautifully designed course. it never gets boring. The best part is that you can learn at your own pace. Thank you all the instructors and Coursera for making the content available.

讲师

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Kenneth J. Pienta, M.D.

The Donald S. Coffey Professor of Urology
The James Buchanan Brady Urological Institute
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Jelani Zarif

Prostate Cancer Researcher
The James Buchanan Brady Urological Institute
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Sarah Amend

Prostate Cancer Researcher
The James Buchanan Brady Urological Institute
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Haley Axelrod

Prostate Cancer Researcher
The James Buchanan Brady Urological Institute
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Kenneth Valkenburg

Prostate Cancer Researcher
The James Buchanan Brady Urological Institute

关于 约翰霍普金斯大学

The mission of The Johns Hopkins University is to educate its students and cultivate their capacity for life-long learning, to foster independent and original research, and to bring the benefits of discovery to the world....

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