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DNA Decoded

总览授课大纲常见问题解答制作方价格评分和审阅

主页生命科学生物

DNA Decoded

麦克马斯特大学

关于此课程: Are you a living creature? Then, congratulations! You’ve got DNA. But how much do you really know about the microscopic molecules that make you unique? Why is DNA called the “blueprint of life”? What is a “DNA fingerprint”? How do scientists clone DNA? What can DNA teach you about your family history? Are Genetically Modified Organisms (GMOs) safe? Is it possible to revive dinosaurs by cloning their DNA? DNA Decoded answers these questions and more. If you’re curious about DNA, join Felicia Vulcu and Caitlin Mullarkey, two biochemists from McMaster University, as they explore the structure of DNA, how scientists cracked the genetic code, and what our DNA can tell us about ourselves. Along the way, you’ll learn about the practical techniques that scientists use to analyze our genetic risks, to manipulate DNA, and to develop new treatments for a range of different diseases. Then, step into our virtual lab to perform your own forensic DNA analysis of samples from a crime scene and solve a murder.


制作方:  麦克马斯特大学
麦克马斯特大学

  • Caitlin Mullarkey

    教学方:  Caitlin Mullarkey, Assistant Professor

    Health Sciences

  • Felicia Vulcu

    教学方:  Felicia Vulcu, Assistant Professor

    Biochemistry and Biomedical Sciences
级别Intermediate
语言
English
如何通过通过所有计分作业以完成课程。
用户评分
4.9 星
平均用户评分 4.9查看学生的留言
授课大纲
第 1 周
Cracking the Genetic Code
In this module, we'll explore the molecular structure of DNA. What is DNA? What are the basic building blocks of DNA? Where can you find DNA within a cell? We'll learn about how James Watson and Francis Crick were able to solve the riddle of the molecular structure of DNA by building on the work of other scientists. Their groundbreaking discovery revealed that four nucleobases (adenine, thymine, cytosine, and guanine) combine with sugar and phosphate molecules to form the familiar double helix of DNA. We'll take a look at how the molecular structure of DNA regulates its functions; for example, how the chemical bonds (covalent and noncovalent) between these molecules allow DNA to "unzip" during replication. Then we'll take a look at how you manage to fit over three billion base pairs into each of your cells. (Here's a hint: Histones, nucleosomes, and chromosomes would be great at packing for a trip!)
7 视频, 4 阅读材料, 5 练习测试
  1. 视频: Meet the Decoders!
  2. Discussion Prompt: Why are you interested in learning about DNA?
  3. 视频: How to Speak DNA
  4. Practice Quiz: How to Speak DNA
  5. 视频: Cracking the Genetic Code
  6. Practice Quiz: Cracking the Genetic Code
  7. Discussion Prompt: What's your inspiration?
  8. 视频: The Building Blocks of DNA
  9. Practice Quiz: The Building Blocks of DNA
  10. 视频: Packing it all in!
  11. Practice Quiz: Packing it all in!
  12. 视频: Summing Up
  13. Practice Quiz: DNA Word Search
  14. Discussion Prompt: What are you curious about?
  15. Discussion Prompt: What was the muddiest point in this lesson for you?
  16. 视频: The Double Helix
  17. Reading: Timeline of DNA Discoveries
  18. Reading: Behind the Picture: Photo 51 (interview)
  19. Reading: (Not Really) The Last Word about DNA (video)
  20. Reading: Biochemistry: The Operating System of Life (video)
已评分: Cracking the Genetic Code
第 2 周
Getting the Message Across: Transcription, Translation, and Replication
We've all heard DNA described as "the blueprint of life," but what does that actually mean? Each one of the approximately 20,000 genes in our bodies contains the instructions for building a protein. In this module, we'll explain how RNA copies the genetic information contained in our genes and uses this information to assemble amino acids into proteins. Scientists call this concept "Central Dogma": DNA makes RNA and RNA makes protein. We'll also explore how we transmit genetic information from one cell to another -- and what happens when things go wrong. Along the way, we'll learn about techniques (such as polymerase chain reactions and gel electrophoresis) that forensic scientists use in DNA fingerprinting. Join us this week for murder and mayhem in the lab!
8 视频, 4 阅读材料, 8 练习测试
  1. Reading: The Case of the Silenced Scientist
  2. 视频: The Scene of the Crime
  3. Practice Quiz: The Scene of the Crime
  4. 视频: Stop copying me! DNA Replication
  5. Practice Quiz: Stop copying me! DNA Replication
  6. 视频: Central Dogma, Part I: Transcription
  7. Practice Quiz: Central Dogma, Pt 1: Transcription
  8. 视频: Central Dogma, Part II: Translation
  9. Practice Quiz: Central Dogma, Pt 2: Translation
  10. Practice Quiz: Decipher the Secret Message
  11. Practice Quiz: Breaking the Code (aka Game of Codons)
  12. 视频: Practical DNA: Polymerase Chain Reaction (PCR)
  13. Practice Quiz: Polymerase Chain Reaction (PCR)
  14. 视频: Practical DNA: Gel Electrophoresis
  15. Practice Quiz: Gel Electrophoresis
  16. 视频: Summing Up
  17. Reading: Labster: Crime Scene Investigation
  18. Discussion Prompt: What are you curious about?
  19. Discussion Prompt: What was the muddiest point in this lesson for you?
  20. 视频: DNA Replication
  21. Reading: TED Talk: Drew Barry - Animations of Unseeable Biology (video)
  22. Reading: Protein Data Bank
已评分: Getting the Message Across
第 3 周
Manipulating DNA
In this module, we'll explore the techniques scientists use to manipulate DNA. Genetic engineering has allowed us to increase crop yields, diagnose illnesses, develop vaccines, and manufacture insulin. By carefully selecting a pair of molecular scissors (restriction enzymes), scientists are able to isolate a gene of interest and insert it into plasmid DNA, turning a common bacteria (E. coli) into a molecular copying machine. This week, we'll learn that mutations are genetic errors, but that not all mutations are necessarily bad — in fact, some mutations confer a selective advantage that protects against disease. We'll explain what genetically modified organisms are (and what they are not) and weigh in on the heated debates about the ethics and safety of GMOs in popular media.
8 视频, 5 阅读材料, 6 练习测试
  1. 视频: Freaky Fruit: Manipulating DNA
  2. Practice Quiz: Freaky Fruit: Manipulating DNA
  3. Discussion Prompt: If you could manipulate DNA, what would you change?
  4. 视频: Slice and Dice: Restriction Enzymes
  5. Practice Quiz: Slice and Dice: Restriction Enzymes
  6. 视频: Lights, Camera, Transformations
  7. Practice Quiz: Lights, Camera, Transformations
  8. 视频: Mutations, Mutations, Mutations!
  9. Practice Quiz: Mutations, mutations, mutations
  10. 视频: From Bananas to Papayas: Genetically Modified Organisms (GMOs)
  11. Practice Quiz: From Papayas to Bananas: Genetically Modified Organisms (GMOs)
  12. Discussion Prompt: Should genetically-modified foods be labelled?
  13. 视频: Summing Up
  14. Practice Quiz: Help Felicia design a blue tomato!
  15. Reading: Labster: Molecular Cloning Simulation
  16. Discussion Prompt: What are you curious about?
  17. Discussion Prompt: What was the muddiest point in this lesson for you?
  18. Reading: Creating Dolly (video)
  19. 视频: Genetic Engineering
  20. Reading: Genetic Engineering and Working with DNA (video)
  21. 视频: Sickle Cell Anemia
  22. Reading: How did they make insulin from recombinant DNA? (article)
  23. Reading: Massive Review Reveals Consensus on GMO Safety (article)
已评分: Manipulating DNA
第 4 周
DNA and Me
What does your DNA say about you? You may have heard that you share 99% of your genetic material with everyone else on the planet. That's true, but this week we're going to take a look at the less than 1% that makes you unique. We'll kick off by discussing the Human Genome Project, the massive scientific collaboration that mapped out the sequence of all our genetic material. The technologies developed while mapping out the human genome ushered in a new age in DNA research. Now, genome-wide association studies can analyze massive amounts of data, searching for genetic variations that are associated with particular diseases. Pharmacogenomics may help determine which drugs are likely be most effective for you. Genetic genealogy tests (such as Ancestry DNA, 23 and Me, and Family Tree DNA) will allow you to trace random mutations in your DNA that can provide clues to your ethnic heritage. As an added bonus, we'll discuss whether it would be possible to revive extinct species by studying ancient DNA.
9 视频, 7 阅读材料, 5 练习测试
  1. 视频: DNA: Our Genetic Blueprint
  2. Practice Quiz: DNA: Our Genetic Blueprint
  3. 视频: Sanger Sequencing
  4. Practice Quiz: Sanger Sequencing
  5. 视频: The Human Genome Project
  6. 视频: Mammoths, Mummies, and Microbes: Ancient DNA
  7. Discussion Prompt: Should we revive extinct species?
  8. 视频: Me and My Family Tree
  9. Practice Quiz: Me and My Family Tree
  10. 视频: DNA and My Health
  11. Practice Quiz: DNA and My Health
  12. Discussion Prompt: What do you think of personal DNA tests?
  13. 视频: That's a wrap!
  14. Reading: Labster: Next Generation Sequencing Simulation
  15. Discussion Prompt: What are you curious about?
  16. Discussion Prompt: What was the muddiest point in this lesson for you?
  17. Reading: Cracking the Code of Life (video)
  18. 视频: Sanger Sequencing
  19. 视频: Human Genome Sequencing
  20. Reading: Iceman Murder Mystery (video)
  21. Reading: Personal DNA Testing (video)
  22. Practice Quiz: Scientists Complete First Chapter of Book of Life With Decoding of First Human Chromosome (article)
  23. Reading: My Career in Genomics: Antibiotic Resistance (video)
  24. Reading: My Career in Genomics: Cancer Biology (video)
  25. Reading: My Career in Genomics: Evolution (video)
已评分: DNA and Me

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制作方
麦克马斯特大学
Founded in 1887, McMaster University is committed to creativity, innovation, and excellence by inspiring critical thinking, personal growth, and a passion for learning. Ranked amongst the Top 100 universities in the world, McMaster pioneered a learner-centred, problem-based, interdisciplinary approach to learning that is now known worldwide as the “McMaster Model”.
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评分和审阅
已评分 4.9,总共 5 个 14 评分
Kaio Mota Ribeiro

Great

DZ

Very interesting course and well explained course. The lab simuklations are wonderful.

LR

Awesome course!

SB

Very informative and would recommend it 100%



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