课程信息
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完成时间大约为30 小时

建议:7 weeks of study, 6-8 hours/week...

英语(English)

字幕:英语(English), 西班牙语(Spanish)

您将获得的技能

CancerMolecular BiologyCancer EpigeneticsDna Methylation

100% 在线

立即开始,按照自己的计划学习。

可灵活调整截止日期

根据您的日程表重置截止日期。

完成时间大约为30 小时

建议:7 weeks of study, 6-8 hours/week...

英语(English)

字幕:英语(English), 西班牙语(Spanish)

教学大纲 - 您将从这门课程中学到什么

1
完成时间为 2 小时

Week 1 - Introduction to Epigenetic Control

7 个视频 (总计 65 分钟), 5 个阅读材料, 1 个测验
7 个视频
1.1 Introduction to the concepts of epigenetic control10分钟
1.2 Mitotic heritability of epigenetic marks10分钟
1.3 Chromatin and the nucleosome6分钟
1.4 Chromatin compaction - heterochromatin versus euchromatin9分钟
1.5 DNA methylation at CpG islands11分钟
1.6 DNA methylation at intergenic regions and repetitive elements15分钟
5 个阅读材料
Course syllabus10分钟
Teaching team10分钟
Start of course survey10分钟
Assessment and grading policy10分钟
Week 1 and 2 resources10分钟
1 个练习
Week 1 quiz - contributes 8% towards your final grade20分钟
2
完成时间为 2 小时

Week 2 - Epigenetic Modifications and Organisation of the Nucleus

9 个视频 (总计 90 分钟), 1 个阅读材料, 1 个测验
9 个视频
2.2 Histone acetylation and histone methylation12分钟
2.3 Chromatin remodelling12分钟
2.4 Histone variants8分钟
2.5 Noncoding RNAs - microRNAs6分钟
2.6 Noncoding RNAs - piRNAs9分钟
2.7 Noncoding RNAs - long noncoding RNAs introduction10分钟
2.8 Long noncoding RNAs Xist and HOTAIR7分钟
2.9 3D organisation of the nucleus and summary of epigenetic marks17分钟
1 个阅读材料
Week 1 and 2 resources10分钟
1 个练习
Week 2 quiz - contributes 8% towards your final grade20分钟
3
完成时间为 3 小时

Week 3 - Dosage Compensation

12 个视频 (总计 113 分钟), 1 个阅读材料, 1 个测验
12 个视频
3.2 Timing of random and imprinted X chromosome inactivation8分钟
3.3 Stages of X inactivation - counting and control of Xist expression13分钟
3.4 Control of Xist expression by pluripotency factors6分钟
3.5 Stages of X inactivation - choice of which X to inactivate9分钟
3.6 Stages of X inactivation - initiation and spreading of silencing11分钟
3.7 Stages of X inactivation - establishment of silencing6分钟
3.8 Stages of X inactivation - maintenance of silencing e.g. Dnmt18分钟
3.9 Stages of X inactivation - maintenance of silencing e.g. Smchd18分钟
3.10 X chromosome inactivation summary10分钟
3.11 Dosage compensation in flies and worms, compared with mammals8分钟
3.12 Lessons from the fly - position effect variegation and screening for epigenetic modifiers10分钟
1 个阅读材料
Week 3 resources (including required readings)10分钟
1 个练习
Week 3 quiz - contributes 12% towards your final grade30分钟
4
完成时间为 2 小时

Week 4 - Genomic Imprinting and Epigenetic Reprogramming

6 个视频 (总计 68 分钟), 1 个阅读材料, 1 个测验
6 个视频
4.2 Epigenetic reprogramming of imprinted genes and repetitive elements11分钟
4.3 Location of imprinted genes in the genome and bisulfite sequencing10分钟
4.4 Kcnq1 and H19/Igf2 ICR mechanisms of action and Beckwith Weidemann syndrome17分钟
4.5 Snrpn ICR mechanism, Prader Willi and Angelman syndromes13分钟
4.6 Summary of epigenetic reprogramming and imprinting6分钟
1 个阅读材料
Week 4 resources (including required reading)10分钟
1 个练习
Week 4 quiz - contributes 12% towards your final grade30分钟
4.8
125 个审阅Chevron Right

33%

完成这些课程后已开始新的职业生涯

38%

通过此课程获得实实在在的工作福利

11%

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来自基因表达的表观遗传调控的热门评论

创建者 MMOct 2nd 2018

This was an excellent course. All the material was well presented and the explanation of the sometimes complex subject matter was clear and understandable. Thank you for an great learning experience.

创建者 DSAug 25th 2018

This is an excellent course that introduces you to fundamental knowledge of several hot topics in the field of epigenetics. Dr. Blewitt herself studies X inactivation, and I learned so much!

讲师

Avatar

Dr. Marnie Blewitt

Head, Molecular Medicine Laboratory
Walter and Eliza Hall Institute of Medical Research

关于 墨尔本大学

The University of Melbourne is an internationally recognised research intensive University with a strong tradition of excellence in teaching, research, and community engagement. Established in 1853, it is Australia's second oldest University....

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