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基因表达的表观遗传调控, 墨尔本大学

4.8
409 个评分
106 个审阅

课程信息

While the human genome sequence has transformed our understanding of human biology, it isn’t just the sequence of your DNA that matters, but also how you use it! How are some genes activated and others are silenced? How is this controlled? The answer is epigenetics. Epigenetics has been a hot topic for research over the past decade as it has become clear that aberrant epigenetic control contributes to disease (particularly to cancer). Epigenetic alterations are heritable through cell division, and in some instances are able to behave similarly to mutations in terms of their stability. Importantly, unlike genetic mutations, epigenetic modifications are reversible and therefore have the potential to be manipulated therapeutically. It has also become clear in recent years that epigenetic modifications are sensitive to the environment (for example diet), which has sparked a large amount of public debate and research. This course will give an introduction to the fundamentals of epigenetic control. We will examine epigenetic phenomena that are manifestations of epigenetic control in several organisms, with a focus on mammals. We will examine the interplay between epigenetic control and the environment and finally the role of aberrant epigenetic control in disease. All necessary information will be covered in the lectures, and recommended and required readings will be provided. There are no additional required texts for this course. For those interested, additional information can be obtained in the following textbook. Epigenetics. Allis, Jenuwein, Reinberg and Caparros. Cold Spring Harbour Laboratory Press. ISBN-13: 978-0879697242 | Edition: 1...

热门审阅

创建者 MM

Oct 02, 2018

This was an excellent course. All the material was well presented and the explanation of the sometimes complex subject matter was clear and understandable. Thank you for an great learning experience.

创建者 DS

Aug 25, 2018

This is an excellent course that introduces you to fundamental knowledge of several hot topics in the field of epigenetics. Dr. Blewitt herself studies X inactivation, and I learned so much!

筛选依据:

102 个审阅

创建者 Donald Brown

Mar 20, 2019

Best cousera I have taken. Extremely well done.

创建者 Afolake Arowolo

Mar 19, 2019

A very good course.

创建者 Neelam Fatima

Mar 01, 2019

it was an excellent course and worth spending time on.

创建者 Mohammad Kazan

Feb 27, 2019

Great and Very informative Course

创建者 Narendra varma

Feb 23, 2019

Its really a fascinating course to learn epigenetics, all classes and materials were really helpful

创建者 NieHu

Feb 16, 2019

nice

创建者 manoj

Nov 25, 2018

Very good and useful

创建者 Hina Khalid

Nov 17, 2018

This course is well taught and some important concepts are repeated over and over again during the course so the concept lingers in the brain as if it was there already.

创建者 Gloria Jemmi Christobel R

Oct 08, 2018

Excellent course

创建者 Mary McPhillips

Oct 02, 2018

This was an excellent course. All the material was well presented and the explanation of the sometimes complex subject matter was clear and understandable. Thank you for an great learning experience.