课程信息
4.7
6 个评分

100% 在线

立即开始,按照自己的计划学习。

可灵活调整截止日期

根据您的日程表重置截止日期。

初级

完成时间大约为16 小时

建议:7 weeks of study, 2-4 hours per week...

英语(English)

字幕:英语(English)

100% 在线

立即开始,按照自己的计划学习。

可灵活调整截止日期

根据您的日程表重置截止日期。

初级

完成时间大约为16 小时

建议:7 weeks of study, 2-4 hours per week...

英语(English)

字幕:英语(English)

教学大纲 - 您将从这门课程中学到什么

1
完成时间为 2 小时

Introduction & Shortcomings of Current Approaches

This module introduces you to the course, outlines the shortcomings of current toxicity testing approaches, and shows how EBT can help to overcome these shortcomings....
9 个视频 (总计 66 分钟), 3 个阅读材料, 1 个测验
9 个视频
Welcome3分钟
Introduction to the Course14分钟
Introduction5分钟
Shortcoming No. 1: Narrative Reviews7分钟
Shortcoming No. 2: Bias in Reviews7分钟
Shortcoming No. 3: Evidence Writing4分钟
Shortcoming No. 4: External Validity10分钟
Shortcoming No. 5: Assessing New Methods5分钟
Shortcoming No. 6: Inadequate Reporting7分钟
3 个阅读材料
Letter to Learners10分钟
Course Learning Objectives10分钟
Supporting reading10分钟
1 个练习
Practice Quiz 18分钟
2
完成时间为 3 小时

History and Causation

This module explains how evidence-based toxicology originated and describes the driving forces for the initiative. In the second lesson, you will learn how to distinguish between correlation and causation as well as the main problems with drawing conclusions on the basis of correlations. The Bradford Hill criteria are introduced, along with examples for each criterion. You will also learn about mechanistic toxicology and mechanistic validation....
11 个视频 (总计 138 分钟), 2 个阅读材料, 1 个测验
11 个视频
Personal First Exposures to Evidence-Based Medicine21分钟
The Start of EBT16分钟
The First Conference 2007 to the Start of the EBT Collaboration 201114分钟
The Evidence-Based Toxicology Collaboration (EBTC)13分钟
Introduction Causation vs. Correlation18分钟
The Hill Principles of Epidemiology and their Relation to Toxicology16分钟
The Problem of Causation in Toxicology16分钟
Biomarker Concept in Mechanistic Toxicology4分钟
Mechanistic Validation4分钟
The Future of Causation in Complex Systems9分钟
2 个阅读材料
Supporting reading10分钟
Supporting reading10分钟
1 个练习
Practice Quiz 210分钟
3
完成时间为 3 小时

Systematic Review and Meta-Analysis

This module shows how to perform systematic reviews and meta-analyses. You will learn the history of both methods and will receive step-by-step instructions on how to perform systematic reviews and meta-analyses using examples from the research activities of the instructors. ...
8 个视频 (总计 101 分钟), 2 个阅读材料, 2 个测验
8 个视频
Systematic Reviews: Definition and Principles26分钟
Systematic Reviews - Protocol Development15分钟
Systematic Reviews - Protocol Development (Part 2)19分钟
History5分钟
Meta-analysis Guidelines7分钟
Meta-analysis Protocol, Part 110分钟
Meta-analysis Protocol, Part 212分钟
2 个阅读材料
Supporting reading10分钟
Supporting reading10分钟
2 个练习
Practice Quiz 36分钟
Mid-course exam30分钟
4
完成时间为 2 小时

Risk of Bias & Application to Test Methods Comparison

This module teaches you about possible biases that can be introduced at different stages of research. Each bias is explained with examples, including solutions for overcoming those biases. The second lesson covers systematic review of the zebrafish embryotoxicity test as a case study conducted by the Evidence-based Toxicology Collaboration (EBTC). You will go through all of the steps of the systematic review again to imprint the knowledge from module 3, but this systematic review will be related to a toxicological method....
8 个视频 (总计 94 分钟), 2 个阅读材料, 1 个测验
8 个视频
Introduction to Risk of Bias Concept in Critical Appraisal of Studies26分钟
Examples for Risk of Bias Tools 1: Cochrane Collboration4分钟
Examples for Risk of Bias Tools 2: SYRCLE's RoB Tool5分钟
Examples of Risk of Bias Tools 3: National Institute for Environmental Health Sciences (NIEHS) - OHAT12分钟
Quality Assessment in Evidence-Based Toxicology7分钟
Evidence-Based Toxicology (EBT) and Evidence-Based Toxicology Collaboration (EBTC)11分钟
Zebrafish Systematic Review22分钟
2 个阅读材料
Supporting reading10分钟
Supporting reading10分钟
1 个练习
Practice Quiz 410分钟

讲师

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Thomas Hartung

Professor
Environmental Health and Engineering
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Lena Smirnova

Research Associate
Center for Alternatives to Animal Testing

关于 约翰霍普金斯大学

The mission of The Johns Hopkins University is to educate its students and cultivate their capacity for life-long learning, to foster independent and original research, and to bring the benefits of discovery to the world....

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