课程信息
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初级

初级

完成时间(小时)

完成时间大约为13 小时

建议:6 hours/week...
可选语言

英语(English)

字幕:英语(English)...
100% 在线

100% 在线

立即开始,按照自己的计划学习。
可灵活调整截止日期

可灵活调整截止日期

根据您的日程表重置截止日期。
初级

初级

完成时间(小时)

完成时间大约为13 小时

建议:6 hours/week...
可选语言

英语(English)

字幕:英语(English)...

教学大纲 - 您将从这门课程中学到什么

1
完成时间(小时)
完成时间为 2 小时

Enzymes, Enzyme Discovery and Engineering

Enzyme catalysts are central to life. They are the vehicles for delivering innovative bioscience solutions to chemicals manufacture, drug discovery, therapeutics and bioprocessing. They are the key enablers in the white biotechnology revolution, providing essential components in the new science of 'synthetic biology', offering new routes to biofuels, bulk and commodity chemicals and novel therapeutics. ...
Reading
8 个视频(共 61 分钟), 2 个阅读材料, 1 个测验
Video8 个视频
Introduction from Nigel Scrutton分钟
Overview and introduction9分钟
How do enzymes work?15分钟
How do we discover enzymes for application in biotechnology?5分钟
How can we study and characterise the catalytic activity of enzymes?7分钟
Engineering Enzymes I: Directed Evolution8分钟
Engineering Enzymes II: Rational Design of Biocatalysts11分钟
Reading2 个阅读材料
Pre Course Survey and Course Credits10分钟
Glossary10分钟
Quiz1 个练习
Enzymes, Enzyme Discovery and Engineering22分钟
2
完成时间(小时)
完成时间为 2 小时

Methods in Systems and Synthetic Biology

Recent advances in our ability to read and write genome sequences on a large scale have led to an ambitious vision for a new generation of biotechnology, often referred to as Synthetic Biology. Synthetic Biology aims at turning biology into an engineering discipline, in which organism engineers use computational tools to design biological systems with novel valuable functionalities, which are then built using advanced high-throughput genetic engineering, and tested by rapid screening technologies that collect diagnostic molecular profiles to drive improved designs in an iterative design-build-test cycle. This module will introduce the engineering concepts that inform Synthetic Biology and the cutting-edge technologies that underlie our dramatically increasing ability to construct living systems with custom-made functionalities. All stages of the design-build-test cycle for novel biosystems will be discussed, with a special focus on their integration in a unified bioengineering platform. Examples will focus on the application of Synthetic Biology as an enabling technology for the bioindustry, especially for the improved microbial production of high-value chemicals and drugs. A section on responsible research and innovation will explore the transformative potential of this innovative technology within a broader socio-economic context, creating awareness of the ethical and political implications of research in this field....
Reading
9 个视频(共 61 分钟), 2 个阅读材料, 1 个测验
Video9 个视频
Introduction to Synthetic Biology: Visions for Biotechnology 2.06分钟
Designing biological systems: Computational modelling and systems biology9分钟
Building biological systems I: Genome synthesis and genome editing9分钟
Controlling and engineering pathways in Synthetic Biology9分钟
Testing Biological Systems Biological debugging using metabolomics8分钟
Deploying biological systems: Perspectives on Responsible Research & Innovation and bioethics I5分钟
Deploying biological systems: Perspectives on Responsible Research & Innovation and bioethics II6分钟
Conclusions and Outlook Systems and Synthetic Biology6分钟
Reading2 个阅读材料
Glossary10分钟
Systems and Synthetic Biology10分钟
Quiz1 个练习
Methods in Systems and Synthetic Biology22分钟
3
完成时间(小时)
完成时间为 2 小时

Biochemical and Bioprocess Engineering

Biochemical and bioprocess engineering is concerned with the design of processes which involve biological transformations to manufacture a range of bio-based chemicals, biopharmaceuticals and biofuels. Through applying knowledge of process constraints, which are usually described mathematically, biochemical engineers are able to design a series of integrated process steps or “unit operations” which together make up a bioprocess. This module will give an appreciation of the key role biochemical engineering has in translating discoveries coming from life sciences and synthetic biology, such as improved microbial platforms for product expression, into economically viable full scale production processes. Key engineering concepts and the problem solving approach required for the design of bioprocesses will be taught by a group of biochemical engineers from The University of Manchester, University College London and Technical University of Denmark....
Reading
8 个视频(共 90 分钟), 1 个测验
Video8 个视频
Introduction from James Lawrence and Michael Sulu分钟
Introduction to Biochemical and Bioprocess Engineering12分钟
Microbial fermentation processes and bioreactor design10分钟
Biocatalysis and enzymatic processes24分钟
Recovery and purification of small molecules11分钟
Recovery and purification of large molecules9分钟
Process economics and scale-up19分钟
Quiz1 个练习
Biochemical and Bioprocess Engineering24分钟
4
完成时间(小时)
完成时间为 2 小时

Pharmaceuticals and Fine Chemicals

This module looks at the production of pharmaceuticals and fine chemicals using biocatalysis. Specifically, we will look at isolated biocatalytic transformations using isolated enzymes or whole cells as catalysts to manufacture commercially important products including pharmaceuticals, industrial monomers and personal care products. This module will be delivered by Dr Andy Wells of CHEM21, Europe’s largest public-private partnership dedicated to the development of manufacturing sustainable pharmaceuticals led by The University of Manchester and the pharmaceutical company GlaxoSmithKline. Dr Wells, alongside Dr Tom Dugmore of The University of York, will look at six industrial examples of biocatalytic reactions involving six different enzyme transformations. Each example will look at the product, manufacturing route, mechanism of the enzyme reaction and some of the sustainability drivers and metrics for adopting IB as part of the manufacturing route. Over the six examples, a number of key attributes of enzyme catalysed processes that need to be considered for successful scale-up will be examined. These include choice of free enzyme or whole cell catalyst, co-factors and co-factor recycling, multi-phase reactions, enzyme stability and throughput. Each example will have a number of references to the primary literature covering the product and enzyme type for further learning outside of the module....
Reading
7 个视频(共 66 分钟), 2 个阅读材料, 1 个测验
Video7 个视频
Industrial Example 1: Hydrolases11分钟
Industrial Example 2: Transaminase11分钟
Industrial Example 3: DERA Aldolase10分钟
Industrial Example 4: Alcohol Dehydrogenases12分钟
Industrial Example 5: Nitrile Hydratases8分钟
Industrial Example 6: Amino Acid Oxidases9分钟
Reading2 个阅读材料
CHEM2110分钟
References and Further Reading10分钟
Quiz1 个练习
Pharmaceuticals and Fine Chemicals24分钟

讲师

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Prof. Nicholas Turner

Deputy Director
Manchester Institute of Biotechnology
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Prof. Nigel Scrutton

Director
Manchester Institute of Biotechnology

关于 University of Manchester

Tracing its roots back to 1824, the University of Manchester is home to almost 40,000 students. The University has three Nobel laureates among its current staff – more than any other British university - and a total of 25 Nobel laureates have come from our past and present students and staff. We have three main goals: to undertake world-class research; to deliver an outstanding learning and student experience; and to be socially responsible....

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