课程信息
4.5
40 个评分
11 个审阅
专项课程

Course 4 of 7 in the

100% 在线

100% 在线

立即开始,按照自己的计划学习。
可灵活调整截止日期

可灵活调整截止日期

根据您的日程表重置截止日期。
初级

初级

完成时间(小时)

完成时间大约为17 小时

建议:3 hours/week...
可选语言

英语(English)

字幕:英语(English)
专项课程

Course 4 of 7 in the

100% 在线

100% 在线

立即开始,按照自己的计划学习。
可灵活调整截止日期

可灵活调整截止日期

根据您的日程表重置截止日期。
初级

初级

完成时间(小时)

完成时间大约为17 小时

建议:3 hours/week...
可选语言

英语(English)

字幕:英语(English)

教学大纲 - 您将从这门课程中学到什么

1
完成时间(小时)
完成时间为 3 小时

Week 1: Introduction to Evolutionary Tree Construction

<p>Welcome to our class!</p><p>In this class, we will consider the following two central biological&nbsp;questions (the computational approaches needed to solve them are shown in parentheses):</p><ol><li>Weeks 1-3: Which Animal Gave Us SARS? (<i>Evolutionary tree construction</i>)</li><li>Weeks 4-5: Was <em>T. rex</em> Just a Big Chicken?&nbsp;(<em>Combinatorial Algorithms</em>)</li></ol><p>In Week 6, you will complete a Bioinformatics Application Challenge to apply evolutionary tree construction algorithms in order to determine the origin of the recent ebola outbreak in Africa.</p><p>As in previous courses, each of these two chapters is accompanied by a Bioinformatics Cartoon created by talented artist Randall Christopher and serving as a chapter header in the Specialization's bestselling <a href="http://bioinformaticsalgorithms.com" target="_blank">print companion</a>. You can find the first chapter's cartoon at the bottom of this message. What do stick bugs and bats have to do with deadly viruses? And how can bioinformatics be used to stop these viruses in their tracks? Start learning today and find out!</p><p><img src="http://bioinformaticsalgorithms.com/images/cover/evolution_cropped.jpg" title="Image: http://bioinformaticsalgorithms.com/images/cover/evolution_cropped.jpg" width="528"></p>...
Reading
5 个视频 (总计 34 分钟), 2 个阅读材料, 3 个测验
Video5 个视频
The Fastest Outbreak 5分钟
Transforming Distance Matrices into Evolutionary Trees 6分钟
Toward an Algorithm for Distance-Based Phylogeny Construction 8分钟
Additive Phylogeny 9分钟
Reading2 个阅读材料
Course Details10分钟
Week 1 FAQs (Optional)0
Quiz1 个练习
Week 1 Quiz15分钟
2
完成时间(小时)
完成时间为 3 小时

Week 2: More Algorithms for Constructing Trees from Distance Matrices

<p>Welcome to Week 2 of class!</p> <p>Last week, we started to see how evolutionary trees can be constructed from distance matrices. &nbsp;This week, we will encounter additional algorithms for this purpose, including the neighbor-joining algorithm, which has become one of the top-ten most cited papers in all of science since its introduction three decades ago.</p>...
Reading
3 个视频 (总计 17 分钟), 1 个阅读材料, 3 个测验
Video3 个视频
Ultrametric Trees 6分钟
The Neighbor-Joining Algorithm 7分钟
Reading1 个阅读材料
Week 2 FAQs (Optional)0
Quiz1 个练习
Week 2 Quiz15分钟
3
完成时间(小时)
完成时间为 4 小时

Week 3: Constructing Evolutionary Trees from Characters

<p>Welcome to week 3 of class!</p> <p>Over the last two weeks, we have seen several different algorithms for constructing evolutionary trees from distance matrices.</p> <p>This week, we will conclude the current chapter by considering what happens if we use properties called "characters" instead of distances. We will also see how to infer the ancestral states of organisms in an evolutionary tree, and consider whether it is possible to define an efficient algorithm for this task.</p>...
Reading
4 个视频 (总计 20 分钟), 1 个阅读材料, 3 个测验
Video4 个视频
The Small Parsimony Algorithm 8分钟
The Large Parsimony Algorithm 3分钟
Evolutionary Tree Reconstruction in the Modern Era 5分钟
Reading1 个阅读材料
Week 3 FAQs (Optional)0
Quiz1 个练习
Week 3 Quiz15分钟
4
完成时间(小时)
完成时间为 1 小时

Week 4

<p>Welcome to week 4 of the class!</p> <p>Did birds evolve from dinosaurs? Over the next two weeks, we will see how we could analyze molecular evidence in support of this theory. You can find this week's Bioinformatics Cartoon from Randall Christopher at the bottom of this E-mail. Why does the <em>T. rex&nbsp;</em>look so much like a chicken? And why is the monkey typing frantically? Keep learning to find out!</p> <p><img src="http://bioinformaticsalgorithms.com/images/cover/proteomics_cropped.jpg" title="Image: http://bioinformaticsalgorithms.com/images/cover/proteomics_cropped.jpg" width="528"></p>...
Reading
4 个视频 (总计 26 分钟), 1 个阅读材料, 2 个测验
Video4 个视频
Decoding an Ideal Spectrum 5分钟
From Ideal to Real Spectra 5分钟
Peptide Sequencing 7分钟
Reading1 个阅读材料
Note on This Week's Assignments10分钟
Quiz1 个练习
Week 4 Quiz15分钟
4.5
11 个审阅Chevron Right

热门审阅

创建者 RGJul 20th 2017

Covers the most important algorithms for phylogenetic trees. Fascinating exam

讲师

Avatar

Pavel Pevzner

Professor
Department of Computer Science and Engineering
Avatar

Phillip Compeau

Visiting Researcher
Department of Computer Science & Engineering

关于 University of California San Diego

UC San Diego is an academic powerhouse and economic engine, recognized as one of the top 10 public universities by U.S. News and World Report. Innovation is central to who we are and what we do. Here, students learn that knowledge isn't just acquired in the classroom—life is their laboratory....

关于 Bioinformatics 专项课程

Join Us in a Top 50 MOOC of All Time! How do we sequence and compare genomes? How do we identify the genetic basis for disease? How do we construct an evolutionary Tree of Life for all species on Earth? When you complete this Specialization, you will learn how to answer many questions in modern biology that have become inseparable from the computational approaches used to solve them. You will also obtain a toolkit of existing software resources built on these computational approaches and that are used by thousands of biologists every day in one of the fastest growing fields in science. Although this Specialization centers on computational topics, you do not need to know how to program in order to complete it. If you are interested in programming, we feature an "Honors Track" (called "hacker track" in previous runs of the course). The Honors Track allows you to implement the bioinformatics algorithms that you will encounter along the way in dozens of automatically graded coding challenges. By completing the Honors Track, you will be a bioinformatics software professional! Learn more about the Bioinformatics Specialization (including why we are wearing these crazy outfits) by watching our introductory video. You can purchase the Specialization's print companion, Bioinformatics Algorithms: An Active Learning Approach, from the textbook website. Our first course, "Finding Hidden Messages in DNA", was named a top-50 MOOC of all time by Class Central!...
Bioinformatics

常见问题

  • 注册以便获得证书后,您将有权访问所有视频、测验和编程作业(如果适用)。只有在您的班次开课之后,才可以提交和审阅同学互评作业。如果您选择在不购买的情况下浏览课程,可能无法访问某些作业。

  • 您注册课程后,将有权访问专项课程中的所有课程,并且会在完成课程后获得证书。您的电子课程证书将添加到您的成就页中,您可以通过该页打印您的课程证书或将其添加到您的领英档案中。如果您只想阅读和查看课程内容,可以免费旁听课程。

还有其他问题吗?请访问 学生帮助中心