关于此 专项课程
100% 在线课程

100% 在线课程

立即开始,按照自己的计划学习。
灵活的计划

灵活的计划

设置并保持灵活的截止日期。
初级

初级

完成时间(小时)

完成时间大约为11 个月

建议 3 小时/周
可选语言

英语(English)

字幕:英语(English), 中文(简体)...

您将获得的技能

Whole Genome SequencingViterbi AlgorithmSuffix TreePython ProgrammingAlgorithmsUnweighted Pair Group Method with Arithmetic Mean (UPGMA)Bioinformatics
100% 在线课程

100% 在线课程

立即开始,按照自己的计划学习。
灵活的计划

灵活的计划

设置并保持灵活的截止日期。
初级

初级

完成时间(小时)

完成时间大约为11 个月

建议 3 小时/周
可选语言

英语(English)

字幕:英语(English), 中文(简体)...

专项课程 的运作方式

加入课程

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在结束每门课程并完成实践项目之后,您会获得一个证书,您可以向您的潜在雇主展示该证书并在您的职业社交网络中分享。

how it works

此专项课程包含 7 门课程

课程1

Finding Hidden Messages in DNA (Bioinformatics I)

4.7
370 个评分
81 个审阅
Named a top 50 MOOC of all time by Class Central! This course begins a series of classes illustrating the power of computing in modern biology. Please join us on the frontier of bioinformatics to look for hidden messages in DNA without ever needing to put on a lab coat. In the first half of the course, we investigate DNA replication, and ask the question, where in the genome does DNA replication begin? We will see that we can answer this question for many bacteria using only some straightforward algorithms to look for hidden messages in the genome. In the second half of the course, we examine a different biological question, when we ask which DNA patterns play the role of molecular clocks. The cells in your body manage to maintain a circadian rhythm, but how is this achieved on the level of DNA? Once again, we will see that by knowing which hidden messages to look for, we can start to understand the amazingly complex language of DNA. Perhaps surprisingly, we will apply randomized algorithms, which roll dice and flip coins in order to solve problems. Finally, you will get your hands dirty and apply existing software tools to find recurring biological motifs within genes that are responsible for helping Mycobacterium tuberculosis go "dormant" within a host for many years before causing an active infection....
课程2

Genome Sequencing (Bioinformatics II)

4.8
162 个评分
34 个审阅
You may have heard a lot about genome sequencing and its potential to usher in an era of personalized medicine, but what does it mean to sequence a genome? Biologists still cannot read the nucleotides of an entire genome as you would read a book from beginning to end. However, they can read short pieces of DNA. In this course, we will see how graph theory can be used to assemble genomes from these short pieces. We will further learn about brute force algorithms and apply them to sequencing mini-proteins called antibiotics. In the first half of the course, we will see that biologists cannot read the 3 billion nucleotides of a human genome as you would read a book from beginning to end. However, they can read shorter fragments of DNA. In this course, we will see how graph theory can be used to assemble genomes from these short pieces in what amounts to the largest jigsaw puzzle ever put together. In the second half of the course, we will discuss antibiotics, a topic of great relevance as antimicrobial-resistant bacteria like MRSA are on the rise. You know antibiotics as drugs, but on the molecular level they are short mini-proteins that have been engineered by bacteria to kill their enemies. Determining the sequence of amino acids making up one of these antibiotics is an important research problem, and one that is similar to that of sequencing a genome by assembling tiny fragments of DNA. We will see how brute force algorithms that try every possible solution are able to identify naturally occurring antibiotics so that they can be synthesized in a lab. Finally, you will learn how to apply popular bioinformatics software tools to sequence the genome of a deadly Staphylococcus bacterium that has acquired antibiotics resistance....
课程3

Comparing Genes, Proteins, and Genomes (Bioinformatics III)

4.7
75 个评分
16 个审阅
Once we have sequenced genomes in the previous course, we would like to compare them to determine how species have evolved and what makes them different. In the first half of the course, we will compare two short biological sequences, such as genes (i.e., short sequences of DNA) or proteins. We will encounter a powerful algorithmic tool called dynamic programming that will help us determine the number of mutations that have separated the two genes/proteins. In the second half of the course, we will "zoom out" to compare entire genomes, where we see large scale mutations called genome rearrangements, seismic events that have heaved around large blocks of DNA over millions of years of evolution. Looking at the human and mouse genomes, we will ask ourselves: just as earthquakes are much more likely to occur along fault lines, are there locations in our genome that are "fragile" and more susceptible to be broken as part of genome rearrangements? We will see how combinatorial algorithms will help us answer this question. Finally, you will learn how to apply popular bioinformatics software tools to solve problems in sequence alignment, including BLAST....
课程4

Molecular Evolution (Bioinformatics IV)

4.5
40 个评分
11 个审阅
In the previous course in the Specialization, we learned how to compare genes, proteins, and genomes. One way we can use these methods is in order to construct a "Tree of Life" showing how a large collection of related organisms have evolved over time. In the first half of the course, we will discuss approaches for evolutionary tree construction that have been the subject of some of the most cited scientific papers of all time, and show how they can resolve quandaries from finding the origin of a deadly virus to locating the birthplace of modern humans. In the second half of the course, we will shift gears and examine the old claim that birds evolved from dinosaurs. How can we prove this? In particular, we will examine a result that claimed that peptides harvested from a T. rex fossil closely matched peptides found in chickens. In particular, we will use methods from computational proteomics to ask how we could assess whether this result is valid or due to some form of contamination. Finally, you will learn how to apply popular bioinformatics software tools to reconstruct an evolutionary tree of ebolaviruses and identify the source of the recent Ebola epidemic that caused global headlines....

讲师

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Pavel Pevzner

Professor
Department of Computer Science and Engineering
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Phillip Compeau

Visiting Researcher
Department of Computer Science & Engineering
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Nikolay Vyahhi

Visiting Scholar
Department of Computer Science and Engineering

关于 University of California San Diego

UC San Diego is an academic powerhouse and economic engine, recognized as one of the top 10 public universities by U.S. News and World Report. Innovation is central to who we are and what we do. Here, students learn that knowledge isn't just acquired in the classroom—life is their laboratory....

常见问题

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  • 此课程完全在线学习,无需到教室现场上课。您可以通过网络或移动设备随时随地访问课程视频、阅读材料和作业。

  • 此专项课程不提供大学学分,但部分大学可能会选择接受专项课程证书作为学分。查看您的合作院校了解详情。

  • The print companion accompanying the Specialization is Bioinformatics Algorithms: An Active Learning Approach (Vols. 1 and 2).

  • Time to completion can vary based on your schedule, but most learners are able to complete the Specialization in 4-6 months.

  • We require only a basic knowledge of high school-level biology and the ability to think technically.

  • We recommend taking the courses in the order presented, as each subsequent course will build on material from previous courses.

  • You will understand the ideas behind many different software tools that are used every day by biotech researchers, and you will know how to apply these tools to real datasets.

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