课程信息
4.8
168 个评分
35 个审阅

100% 在线

立即开始,按照自己的计划学习。

可灵活调整截止日期

根据您的日程表重置截止日期。

完成时间大约为14 小时

建议:2-4 hours/week...

英语(English)

字幕:英语(English)

100% 在线

立即开始,按照自己的计划学习。

可灵活调整截止日期

根据您的日程表重置截止日期。

完成时间大约为14 小时

建议:2-4 hours/week...

英语(English)

字幕:英语(English)

教学大纲 - 您将从这门课程中学到什么

1
完成时间为 3 小时

UNIT 1: INTRODUCTION TO PERSONALIZED MEDICINE

The first module of this course will focus on introducing the concept of personalized medicine. We will very briefly review fundamentals of genetics as these apply to personalized medicine (DNA structure; RNA; protein structures; function of DNA; coding; DNA variations; types of genetic variants), as well as review statistical concepts and skills important to clinical data analysis (odds ratios, relative risk, P values, multiple testing, sensitivity, specificity, ROCs). In Module 2 we will explore drug actions and reactions as we look closely at the general mechanisms underlying variability in drug responses, drug metabolism and transport, and genetic variability in drug-handling molecules....
11 个视频 (总计 120 分钟), 1 个阅读材料, 1 个测验
11 个视频
Introduction to Personalized Medicine11分钟
Genetics Definitions, Part I14分钟
Genetics Definitions, Part II & Types of Genetic Variants15分钟
Data Analysis, Part I: What is a Good Study?12分钟
Data Analysis, Part II: What is a Good Test?7分钟
Introduction to Drug Therapy and General Mechanisms Underlying Variability in Drug Responses13分钟
Variability in Drug Therapy15分钟
Drug Metabolism & Transport13分钟
Genetic Variability in Drug-Handling Molecules10分钟
**Inside VUMC: The Promise of Personalized Medicine1分钟
1 个阅读材料
About this course10分钟
1 个练习
Introduction to Personalized Medicine12分钟
2
完成时间为 2 小时

UNIT 2: STUDYING GENETIC VARIATION

Module 3 focuses on how we study genetic variation. We'll start by looking at families and populations. Topics that will be introduced include family history and inheritance patterns, ancestry, and linkage. Then in Module 4 we shift our focus to studying the contemporary techniques and technologies used to study genetic variation, including genome-wide association and sequencing....
7 个视频 (总计 104 分钟), 1 个测验
7 个视频
Ancestry: Genetic Variation Across Generations and Geography17分钟
Finding Disease-Associated Genes: Linkage10分钟
**Inside VUMC: From Phenotype to Genotype and Back: Studying Heart Disease in Families1分钟
Genome-Wide Association25分钟
Sequencing28分钟
**Inside VUMC: History of Sequencing Technologies1分钟
1 个练习
Studying Genetic Variation12分钟
3
完成时间为 3 小时

UNIT 3: CASE STUDIES IN PERSONALIZED MEDICINE, PART 1

In Module 5 we will begin to discuss specific cases as these apply to personalized medicine. We will first look very closely at a case of familial hypercholesterolemia as we investigate how we use genomic medicine to move from a rare disease to a common medication, using genomics to find new drug targets, and a discussion of the side effects of statin therapy. In Module 6 we will look at a collection of "high risk pharmacogenetics"cases that illustrate adverse reactions due to drug metabolism and variable drug responses....
13 个视频 (总计 174 分钟), 1 个测验
13 个视频
Using Genomics to Find New Drug Targets: Familial Hypercholesterolemia16分钟
Muscle Pains During Statin Therapy (Myopathy)13分钟
HLA-Mediated Immune Reactions (Skin Rash)9分钟
Long QT Syndromes, Part 115分钟
Long QT Syndromes, Part 218分钟
**Inside VUMC: Studying Cardiac Arrhythmias in Cells4分钟
A Second Heart Attack a Month After a First15分钟
Headache During Venlafaxine (Antidepressant)16分钟
Respiratory Arrest After Tonsillectomy10分钟
A Bleeding Complication 5 Days After Starting Warfarin21分钟
**Inside VUMC: Genotyping1分钟
Drug Metabolism and Variable Drug Responses – Four More Examples17分钟
1 个练习
Case Studies, Part I16分钟
4
完成时间为 2 小时

UNIT 4: CASE STUDIES IN PERSONALIZED MEDICINE, PART 2

Module 7 continues our focus on case studies with a look at some cases that illustrate how personalized medicine informs treatment decisions related to specific diseases/conditions. These include cystic fibrosis, Marfan syndrome, heart failure, neuropsychiatric diseases, and diabetes. Three cases/lessons focus specifically on how genomic medicine informs testing for and treatment of cancer. ...
9 个视频 (总计 119 分钟), 1 个测验
9 个视频
Marfan Syndrome11分钟
A Case of Idiopathic Heart Failure16分钟
Personalizing Care in Neuropsychiatric Disease18分钟
Personalizing Care in Diabetes21分钟
Genomics to Subtype Cancer11分钟
A Family Member With Breast Cancer14分钟
A Family Member With Colon Cancer11分钟
**Inside VUMC: Organizing Infrastructure to Support Genetic Testing Decisions1分钟
1 个练习
Case Studies, Part II10分钟
4.8
35 个审阅Chevron Right

17%

完成这些课程后已开始新的职业生涯

25%

通过此课程获得实实在在的工作福利

33%

加薪或升职

热门审阅

创建者 MTApr 24th 2017

I learned more about pharmacogenomics and its application, which is crucial for my career development as a young graduate in biology who is pursuing health sciences.

创建者 CZNov 13th 2016

Thank you! I think I'm going to review/re-take this course at least one more time as the lectures are really interesting and insightful.

讲师

Avatar

Dan Roden, M.D.

Professor of Medicine and Pharmacology
Assistant Vice Chancellor for Personalized Medicine

关于 范德堡大学

Vanderbilt University, located in Nashville, Tenn., is a private research university and medical center offering a full-range of undergraduate, graduate and professional degrees....

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