课程信息
4.8
140 ratings
30 reviews
Learn how advances in biomedicine hold the potential to revolutionize drug development, drug treatments, and disease prevention: where are we now, and what does the future hold? This course will present short primers in genetics and mechanisms underlying variability in drug responses. A series of case studies will be used to illustrate principles of how genetics are being brought to bear on refining diagnoses and on personalizing treatment in rare and common diseases. The ethical and operational issues around how to implement large scale genomic sequencing in clinical practice will be addressed. After completing this course, learners will understand 1. The ways in which genetic variants can contribute to human disease susceptibility 2. How to choose among drug therapies based on genetic factors 3. That the functional consequences of the vast majority of genetic variants discovered by modern sequencing are unknown. This course is targeted primarily at physicians 5+ years out of training. Other healthcare providers, medical/health sciences students, and members of the public may also be interested. Course launches January 15, 2016. * The information presented in “Case Studies in Personalized Medicine” is offered for educational and informational purposes only, and should not be construed as personal medical advice. If you have questions or concerns about a medical matter, please consult your doctor or other professional healthcare provider....
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建议:2-4 hours/week

完成时间大约为14 小时
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字幕:English
Globe

100% 在线课程

立即开始,按照自己的计划学习。
Calendar

可灵活调整截止日期

根据您的日程表重置截止日期。
Clock

建议:2-4 hours/week

完成时间大约为14 小时
Comment Dots

English

字幕:English

教学大纲 - 您将从这门课程中学到什么

1

章节
Clock
完成时间为 3 小时

UNIT 1: INTRODUCTION TO PERSONALIZED MEDICINE

The first module of this course will focus on introducing the concept of personalized medicine. We will very briefly review fundamentals of genetics as these apply to personalized medicine (DNA structure; RNA; protein structures; function of DNA; coding; DNA variations; types of genetic variants), as well as review statistical concepts and skills important to clinical data analysis (odds ratios, relative risk, P values, multiple testing, sensitivity, specificity, ROCs). In Module 2 we will explore drug actions and reactions as we look closely at the general mechanisms underlying variability in drug responses, drug metabolism and transport, and genetic variability in drug-handling molecules....
Reading
11 个视频(共 120 分钟), 1 个阅读材料, 1 个测验
Video11 个视频
Introduction to Personalized Medicine11分钟
Genetics Definitions, Part I14分钟
Genetics Definitions, Part II & Types of Genetic Variants15分钟
Data Analysis, Part I: What is a Good Study?12分钟
Data Analysis, Part II: What is a Good Test?7分钟
Introduction to Drug Therapy and General Mechanisms Underlying Variability in Drug Responses13分钟
Variability in Drug Therapy15分钟
Drug Metabolism & Transport13分钟
Genetic Variability in Drug-Handling Molecules10分钟
**Inside VUMC: The Promise of Personalized Medicine1分钟
Reading1 个阅读材料
About this course10分钟
Quiz1 个练习
Introduction to Personalized Medicine12分钟

2

章节
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完成时间为 2 小时

UNIT 2: STUDYING GENETIC VARIATION

Module 3 focuses on how we study genetic variation. We'll start by looking at families and populations. Topics that will be introduced include family history and inheritance patterns, ancestry, and linkage. Then in Module 4 we shift our focus to studying the contemporary techniques and technologies used to study genetic variation, including genome-wide association and sequencing....
Reading
7 个视频(共 104 分钟), 1 个测验
Video7 个视频
Ancestry: Genetic Variation Across Generations and Geography17分钟
Finding Disease-Associated Genes: Linkage10分钟
**Inside VUMC: From Phenotype to Genotype and Back: Studying Heart Disease in Families1分钟
Genome-Wide Association25分钟
Sequencing28分钟
**Inside VUMC: History of Sequencing Technologies1分钟
Quiz1 个练习
Studying Genetic Variation12分钟

3

章节
Clock
完成时间为 3 小时

UNIT 3: CASE STUDIES IN PERSONALIZED MEDICINE, PART 1

In Module 5 we will begin to discuss specific cases as these apply to personalized medicine. We will first look very closely at a case of familial hypercholesterolemia as we investigate how we use genomic medicine to move from a rare disease to a common medication, using genomics to find new drug targets, and a discussion of the side effects of statin therapy. In Module 6 we will look at a collection of "high risk pharmacogenetics"cases that illustrate adverse reactions due to drug metabolism and variable drug responses....
Reading
13 个视频(共 174 分钟), 1 个测验
Video13 个视频
Using Genomics to Find New Drug Targets: Familial Hypercholesterolemia16分钟
Muscle Pains During Statin Therapy (Myopathy)13分钟
HLA-Mediated Immune Reactions (Skin Rash)9分钟
Long QT Syndromes, Part 115分钟
Long QT Syndromes, Part 218分钟
**Inside VUMC: Studying Cardiac Arrhythmias in Cells4分钟
A Second Heart Attack a Month After a First15分钟
Headache During Venlafaxine (Antidepressant)16分钟
Respiratory Arrest After Tonsillectomy10分钟
A Bleeding Complication 5 Days After Starting Warfarin21分钟
**Inside VUMC: Genotyping1分钟
Drug Metabolism and Variable Drug Responses – Four More Examples17分钟
Quiz1 个练习
Case Studies, Part I16分钟

4

章节
Clock
完成时间为 2 小时

UNIT 4: CASE STUDIES IN PERSONALIZED MEDICINE, PART 2

Module 7 continues our focus on case studies with a look at some cases that illustrate how personalized medicine informs treatment decisions related to specific diseases/conditions. These include cystic fibrosis, Marfan syndrome, heart failure, neuropsychiatric diseases, and diabetes. Three cases/lessons focus specifically on how genomic medicine informs testing for and treatment of cancer. ...
Reading
9 个视频(共 119 分钟), 1 个测验
Video9 个视频
Marfan Syndrome11分钟
A Case of Idiopathic Heart Failure16分钟
Personalizing Care in Neuropsychiatric Disease18分钟
Personalizing Care in Diabetes21分钟
Genomics to Subtype Cancer11分钟
A Family Member With Breast Cancer14分钟
A Family Member With Colon Cancer11分钟
**Inside VUMC: Organizing Infrastructure to Support Genetic Testing Decisions1分钟
Quiz1 个练习
Case Studies, Part II10分钟
4.8

热门审阅

创建者 MTApr 24th 2017

I learned more about pharmacogenomics and its application, which is crucial for my career development as a young graduate in biology who is pursuing health sciences.

创建者 CZNov 13th 2016

Thank you! I think I'm going to review/re-take this course at least one more time as the lectures are really interesting and insightful.

讲师

Dan Roden, M.D.

Professor of Medicine and Pharmacology
Assistant Vice Chancellor for Personalized Medicine

关于 Vanderbilt University

Vanderbilt University, located in Nashville, Tenn., is a private research university and medical center offering a full-range of undergraduate, graduate and professional degrees....

常见问题

  • Once you enroll for a Certificate, you’ll have access to all videos, quizzes, and programming assignments (if applicable). Peer review assignments can only be submitted and reviewed once your session has begun. If you choose to explore the course without purchasing, you may not be able to access certain assignments.

  • When you purchase a Certificate you get access to all course materials, including graded assignments. Upon completing the course, your electronic Certificate will be added to your Accomplishments page - from there, you can print your Certificate or add it to your LinkedIn profile. If you only want to read and view the course content, you can audit the course for free.

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