This course is geared towards starting undergraduate students. A solid background in biology will be helpful but not absolutely essential. The material will be of interest to those who are pursuing a career in any of the life sciences as well as anyone who has run up against their biological clock.
教学大纲 - 您将从这门课程中学到什么
周
1完成时间为 2 小时
WEEK 1
Introduction to 'chronobiology'. What sorts of rhythms are observed in nature? Most of the lecture will be spent on describing daily or circadian rhythms in organisms from bacteria to man.
9 个视频 （总计 62 分钟）, 1 个阅读材料, 2 个测验
9 个视频
1.1 The Family of Biological Rhythms 7分钟
1.2 The Circa-Rhythms5分钟
1.3 Spatial and Temporal Niches3分钟
1.4 The Case of Gonyaulax polyedra 6分钟
1.5 Introduction to the Second Half of Lecture 1 50
1.6 Circadian Rhythms in Mammals 7分钟
1.7 Circadian Clocks in Flies, Plants and Fungi12分钟
1.8 Wrap up for Lecture 118分钟
1 个阅读材料
Literature suggestion10分钟
2 个练习
Lecture 1, Introduction, first half.10分钟
Lecture 1, Introduction, second half.10分钟
周
2完成时间为 1 小时
WEEK 2
Circadian rhythms synchronise to the 24-hour environment. Organisms use specialised photoreceptors to do this and they display characteristic properties in this process. We experience this active synchronisation process for example when we suffer from jet lag!
5 个视频 （总计 46 分钟）, 3 个阅读材料, 1 个测验
5 个视频
2.1 Pittendrigh´s generalisations 1-9 17分钟
2.2 Pittendrigh´s generalisations 10 and 11 7分钟
2.3 Pittendrigh´s generalisations 12-16 and entrainment11分钟
2.4 Wrap-up for Lecture 28分钟
3 个阅读材料
Literature suggestion10分钟
Translation of de Mairan's botanical observation5分钟
Obituary Jürgen Aschoff10分钟
1 个练习
Formalisms12分钟
周
3完成时间为 1 小时
WEEK 3
We will discuss the elaborate molecular mechanisms that allow circadian clocks to produce their daily rhythms and to synchronise them to its environment. We will compare these mechanisms in a wide range of organisms.
8 个视频 （总计 62 分钟）, 1 个阅读材料, 1 个测验
8 个视频
3.1 The first clock gene8分钟
3.2 The negative feedback hypothesis 15分钟
3.3 More clock genes -many more! 5分钟
3.4 Post transcriptional mechanisms and the clock 11分钟
3.5 Indications of a non-transcriptional clock 6分钟
3.6 Zeitgebers and the molecular clockwork9分钟
3.7 Wrap-up to Lecture 34分钟
1 个阅读材料
Literature suggestion10分钟
1 个练习
Lecture 3 Molecular mechanisms12分钟
周
4完成时间为 1 小时
WEEK 4
Circadian clocks serve to orchestrate physiology and metabolism in a coordinated way over the course of the day. Therefore, practically all processes in an organism are regulated outputs of the clock. We'll discuss examples of these processes and ideas about how this circadian regulation works.
8 个视频 （总计 60 分钟）, 1 个阅读材料, 1 个测验
8 个视频
4.1 Clock control: which processes in humans and how to measure them? 10分钟
4.2 Schwänzeltanz 5分钟
4.3 The SCN regulates the timing of physiology and behaviour 3分钟
4.4 Clock controlled genes (ccg´s) 14分钟
4.5 Clock regulation of behaviour: genetic mechanisms 5分钟
4.6 Clock regulation of other major regulatory systems 4分钟
4.7 Wrap-Up to Lecture 414分钟
1 个阅读材料
Literature suggestion10分钟
1 个练习
Lecture 4: Clock control10分钟
周
5完成时间为 1 小时
WEEK 5
With the appreciation of the clock’s global control, we proceed to discussing how much this temporal programme controls our lives from birth to death and how much we mistreat the circadian clock in modern life.
6 个视频 （总计 58 分钟）, 1 个阅读材料, 1 个测验
6 个视频
5.1 Chronotypes11分钟
5.2 What makes up Chronotypes?8分钟
5.3 Linking chronotype and light entrainment12分钟
5.4 How modern life styles affect sleep7分钟
5.5 Wrap-up to Lecture 516分钟
1 个阅读材料
The link to the MCTQ10分钟
1 个练习
Human12分钟
周
6完成时间为 5 小时
WEEK 6
Finally, we will look at the clock’s relationship to pathology. What are the consequences of living against the clock, what happens if the clock ‘breaks’, and how can we use our knowledge about the circadian system in medical diagnosis and therapy.
11 个视频 （总计 77 分钟）, 4 个测验
11 个视频
6.1 What is normal and what not and why? 9分钟
6.2 The consequences of living against the clock11分钟
6.3 Circadian changes and Pathologies - comorbidities or causal factors 3分钟
6.4 Introduction to the Second Half of Lecture 6 1分钟
6.5 Clock genes that can really mess up the timing of sleep8分钟
6.6 The clock gene mutant mice are sick 8分钟
6.7 Chronopharmacology and chronochemotherapy 4分钟
6.8 The circadian clock is a fitness characteristic8分钟
6.9 Wrap-up to Lecture 613分钟
6.10 Farewell from your CircaClock Team 6分钟
3 个练习
Final Exam "Circaclock"58分钟
Pathology8分钟
Lecture 6. Clock and pathologies8分钟
讲师
Martha Merrow
ProfessorMedical Psychology
Till Roenneberg
ProfessorMedical Psychology
关于 路德维希马克西米利安慕尼黑大学
As one of Europe's leading research universities, LMU Munich is committed to the highest international standards of excellence in research and teaching. Building on its 500-year-tradition of scholarship, LMU covers a broad spectrum of disciplines, ranging from the humanities and cultural studies through law, economics and social studies to medicine and the sciences.
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