关于此课程： This course is geared towards starting undergraduate students. A solid background in biology will be helpful but not absolutely essential. The material will be of interest to those who are pursuing a career in any of the life sciences as well as anyone who has run up against their biological clock.
制作方： Ludwig-Maximilians-Universität München (LMU)
教学方： Martha Merrow, Professor
Medical Psychology教学方： Till Roenneberg, Professor
Medical Psychology
| 语言 | 英语（English） |
| 如何通过 | 通过所有计分作业以完成课程。 |
授课大纲
第 1 周
WEEK 1
Introduction to 'chronobiology'. What sorts of rhythms are observed in nature? Most of the lecture will be spent on describing daily or circadian rhythms in organisms from bacteria to man.
9 个视频, 1 个阅读材料
- 视频: 1.1 The Family of Biological Rhythms
- 视频: 1.2 The Circa-Rhythms
- 视频: 1.3 Spatial and Temporal Niches
- 视频: 1.4 The Case of Gonyaulax polyedra
- 视频: 1.5 Introduction to the Second Half of Lecture 1
- 视频: 1.6 Circadian Rhythms in Mammals
- 视频: 1.7 Circadian Clocks in Flies, Plants and Fungi
- 视频: 1.8 Wrap up for Lecture 1
- Reading: Literature suggestion
已评分: Lecture 1, Introduction, first half.
已评分: Lecture 1, Introduction, second half.
第 2 周
WEEK 2
Circadian rhythms synchronise to the 24-hour environment. Organisms use specialised photoreceptors to do this and they display characteristic properties in this process. We experience this active synchronisation process for example when we suffer from jet lag!
5 个视频, 3 个阅读材料
- 视频: 2.1 Pittendrigh´s generalisations 1-9
- 视频: 2.2 Pittendrigh´s generalisations 10 and 11
- 视频: 2.3 Pittendrigh´s generalisations 12-16 and entrainment
- 视频: 2.4 Wrap-up for Lecture 2
- Reading: Literature suggestion
- Reading: Translation of de Mairan's botanical observation
- Reading: Obituary Jürgen Aschoff
已评分: Formalisms
第 3 周
WEEK 3
We will discuss the elaborate molecular mechanisms that allow circadian clocks to produce their daily rhythms and to synchronise them to its environment. We will compare these mechanisms in a wide range of organisms.
8 个视频, 1 个阅读材料
- 视频: 3.1 The first clock gene
- 视频: 3.2 The negative feedback hypothesis
- 视频: 3.3 More clock genes -many more!
- 视频: 3.4 Post transcriptional mechanisms and the clock
- 视频: 3.5 Indications of a non-transcriptional clock
- 视频: 3.6 Zeitgebers and the molecular clockwork
- 视频: 3.7 Wrap-up to Lecture 3
- Reading: Literature suggestion
已评分: Lecture 3 Molecular mechanisms
第 4 周
WEEK 4
Circadian clocks serve to orchestrate physiology and metabolism in a coordinated way over the course of the day. Therefore, practically all processes in an organism are regulated outputs of the clock. We'll discuss examples of these processes and ideas about how this circadian regulation works.
8 个视频, 1 个阅读材料
- 视频: 4.1 Clock control: which processes in humans and how to measure them?
- 视频: 4.2 Schwänzeltanz
- 视频: 4.3 The SCN regulates the timing of physiology and behaviour
- 视频: 4.4 Clock controlled genes (ccg´s)
- 视频: 4.5 Clock regulation of behaviour: genetic mechanisms
- 视频: 4.6 Clock regulation of other major regulatory systems
- 视频: 4.7 Wrap-Up to Lecture 4
- Reading: Literature suggestion
已评分: Lecture 4: Clock control
第 5 周
WEEK 5
With the appreciation of the clock’s global control, we proceed to discussing how much this temporal programme controls our lives from birth to death and how much we mistreat the circadian clock in modern life.
6 个视频, 1 个阅读材料
- 视频: 5.1 Chronotypes
- 视频: 5.2 What makes up Chronotypes?
- 视频: 5.3 Linking chronotype and light entrainment
- 视频: 5.4 How modern life styles affect sleep
- 视频: 5.5 Wrap-up to Lecture 5
- Reading: The link to the MCTQ
已评分: Human
第 6 周
WEEK 6
Finally, we will look at the clock’s relationship to pathology. What are the consequences of living against the clock, what happens if the clock ‘breaks’, and how can we use our knowledge about the circadian system in medical diagnosis and therapy.
11 个视频, 1 个练习测验
- 视频: 6.1 What is normal and what not and why?
- 视频: 6.2 The consequences of living against the clock
- 视频: 6.3 Circadian changes and Pathologies - comorbidities or causal factors
- 视频: 6.4 Introduction to the Second Half of Lecture 6
- 视频: 6.5 Clock genes that can really mess up the timing of sleep
- 视频: 6.6 The clock gene mutant mice are sick
- 视频: 6.7 Chronopharmacology and chronochemotherapy
- 视频: 6.8 The circadian clock is a fitness characteristic
- 视频: 6.9 Wrap-up to Lecture 6
- 视频: 6.10 Farewell from your CircaClock Team
- Practice Quiz: Final Exam "Circaclock"
- Peer Review: Peer-Reviewed Assignment
已评分: Pathology
已评分: Lecture 6. Clock and pathologies
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制作方
Ludwig-Maximilians-Universität München (LMU)
As one of Europe's leading research universities, LMU Munich is committed to the highest international standards of excellence in research and teaching. Building on its 500-year-tradition of scholarship, LMU covers a broad spectrum of disciplines, ranging from the humanities and cultural studies through law, economics and social studies to medicine and the sciences.
